I don’t think so Guy. All of the shows we’ve counted so far are actually set in the location listed. Of the top 20 cities by population, only two have not had programs based on them. I’ll compile what we have so far:
New York - Friends, et al.
Los Angeles - Starsky and Hutch
Chicago - E.R., Due South
Houston - Houston Knights
Philadelphia - Thirtysomething, Angie, Tony Randall Show
San Diego - Harry O, Mahunt, Simon and Simon
Detroit - Martin
Dallas - Dallas
Phoenix - Alice
San Antonio - The Brothers Garcia
San Jose
Indianapolis - One Day at a Time
San Francisco - The Streets of San Francisco
Jacksonville - Safe Harbor, The Pointman
Columbus - Family Ties
Austin - Austin Stories, Lonesome Dove
Baltimore - Homicide: Life on the Streets
Memphis
Milwaukee - Happy Days, LAverne & Shirley
Boston - Cheers
San Jose’s population is ~894,943 and Memphis is ~650,100.
I’m having fun with this topic, so let’s go further down the list and find more suspect cities. It gets a lot thinner. I’ve highlighted the one’s for which I couldn’t find a TV series. Here’s 21-50.
Washington, D.C - The District
Nashville
El Paso
Seattle - Frasier
Denver - Dynasty
Charlotte, NC
Fort Worth, TX
Portland, OR - Hello, Larry
Oklahoma City, OK
Tucson, AZ
New Orleans, LA - Longstreet
Las Vegas, NV - CSI
Cleveland, Ohio - The Drew Carey Show
Long Beach, CA - Popular?
Albuquerque - The Man and the City, Nakia
Kansas City, MO - The Popcorn Kid
Fresno
Virginia Beach, VA
Atlanta, GA - Designing Women
Sacramento
Oakland, CA - Hangin With Mr. Cooper
Mesa, AZ
Tulsa, OK
Omaha, Neb.
Minneapolis, MN - Mary Tyler Moore Show
Honolulu, HI - Hawaii Five-O
Miami - Miami Vice
Colorado Springs, CO - Dr. Quinn Medicine Woman
St. Louis, MO
Wichita, KS
I hope someone can come along and fill in the blanks 