I was thinking about major US cities with no TV set there. Here’s a list I came up with. Please add (or subtract) from it.
Pittsburgh
Memphis
Indianapolis
San Antonio
Houston
New Orleans
Birmingham
St. Louis
Kansas City (MO)
San Diego
Pittsburgh–Mr. Belvedere
Indianapolis–One Day at a Time
Houston–Houston Knights (late 80s)
New Orleans–Frank’s Place (same era)
San Diego–Simon and Simon
I don’t think Salt Lake City has hosted any sitcoms or dramas (although “Donny and Marie” did air from Utah for a season).
:smack: Thanks! I loved Mr. Belvedere! Didn’t watch *Houston Knights *or Frank’s Place. Too young for others.
Memphis had the TV series Memphis Beat set there as well as the guilty pleasure Hellcats. New Orleans also had the TV adaptation of* The Big Easy*.
Birmingham -Any Day Now
And how could you forget CSI:San Antonio? I guess because it was never made.
Birmingham: Any Day Now
St. Louis: The John Larroquette Show
Kansas City: Apple Pie
Just look in this list:
http://en.wikipedia.org/wiki/List_of_American_television_series_by_setting
Big Love was set in a suburb of Salt Lake City.
I had to think a minute about what you meant—my first instinct was, “Hey, don’t lots of people in those cities have TV sets?”
Then I thought, “If professional sports (e.g. ballgames) count, there are plenty of broadcasts that are set in most of those cities.”
It took a little thinking to decipher the OP.
Sorry gang! I also was limiting it to scripted shows.
First one I thought of, with Bonnie Franklin dying yesterday and all.
Thanks Wendell! The link had me :smack: constantly.
Another show set in Pittsburgh was Queer As Folk on Showtime.
New Orleans:
New Orleans also has Treme.
How about San Jose? Don’t see that in the Wiki-list. Any TV shows set there?
No one’s come up with a San Antonio show. That would make it the largest city with no show, followed by San Jose, if that has none.
Just take that list with a grain of salt. On a quick glance, a few entries were questionable. For example, I’m pretty sure that TJ Hooker was not set in Miami.
Fargo, ND
(Wow…they have cities in North Dakota? I kinda assumed there were just spots where the missile silos were slightly more thick on the ground. 
)
According to The Complete Directory of Prime Time Network and Cable TV Show for San Antonio there is:
The Brothers Garcia (2000-2004 on Nickelodeon, 2004-2005 on CBS Saturday mornings).
Found three previous threads on this topic here on SD and all determined that San Jose was the largest city without a show set in it. But that might be coming to an end. HBO has a new comedy series coming called Silicon Valley. Now, “Silicon Valley” is more than San Jose but San Jose is part of Silicon Valley. So I guess it depends on how loose we want to be.
For New Orleans, don’t forget “Chief Wiggum, P.I.”
(Oh, I’m sorry. You were only asking about real TV shows.)