Long running shows that follow real world physics except for one scene.

Anybody got any good examples of long-running TV shows that take place in the real world, use real physics and have no mystical elements except for one scene of one episode where there is an unambiguous piece of supernaturalness?

2 that made me think of it:

In Chancer, the main character talks to a ghost.

In The Brittas Empire, Gordon genuinely gets killed, and annoys St Peter so much he gets sent back to Earth.

Not quite along the same lines, but in “How I Met Your Mother,” there was an episode where at least three people claimed to have seen and captured some sort of mouse/cockroach hybrid.