Let’s list all the genuine, busily tampering in God’s domain with a
few screws loose Mad Scientists who are at least recurring
characters in a TV show, comics strip or movie.
should be fun 
Rick Hundecoph
Washu Habiki
Victor Frankenstien
Nikola Tesla
Mad Dr. Nesbit
Freddy Frankenstien
Dr. Frank N. Furter
Dr. Zap
Dr. Strangelove
drat!
forgot to mention books.
and books.
-Willy Wonka
Dr. Clayton Forrester (MST3K not War of the Worlds)
Dexter
Dr. Doom
Doc Octopus
Does Lex Luthor count?
Aw heck, the comics are full of them.
Q, from James Bond (sorta)
The guy in The Fly (either version)
Dr. Mephisto, from South Park.
Dr. Noonian Soong, from Star Trek (If a holographic re-creation and MANY references in other episodes count as appearances)
Ranchoth
Leave us not forget Pearl.
I hate to break it to you, but Nikola Tesla was a real person.
Ranchoth, Dr. Soong also turned up alive in one episode.
Doc Brown from the Back To The Future movies.
Dr. Moreau
Dr. Henry Jekyll
Professor Frink
Let us not forget - the first, the greatest movie Mad Scientist:
Rotwang from Metropolis
…oh, what about the guy from Futurama, what was the name again?
That would be Prof. Farnsworth.
Also: Simon Bar Sinister (or is it Barsinister? I’ve seen both.)
Dr. Thaddeus “Bodog” Sivana
HOW CAN YOU MENTION TAMPERING IN GOD’S DOMAIN WITHOUT MENTIONING Dr. Eric Vornoff !?!?!?!!? (BRIDE OF THE MONSTER)
I wonder if these guys went to that same academy that called them all mad?
You know they each get that speech:
“They called me mad at the academy! But I’ll show them I’ll show them all! NOW WHO IS MAD HAH AHAHHAHAHAHHAH!”
(proper answer: “Uh you are sir.”)
Also from the Superman mythos, let’s include:
Professor Periwinkle (pre-Crisis)
Emil Hamilton (post-Crisis)
May we include Gyro Gearloose?
The Brain, of Pinky and the Brain. And who was the guy from G. I. Joe?
Let’s not forget Temple Fugate, the Clock King.
From Bride of Frankenstein, there’s Dr. Pretorius.
Dr. Mindbender!!!
That guy who is the Lizard in Spiderman is a scientist when he is not a crazy lizard man.
Dr Helen Narbon (not to mention her mother, and what’s-his-name)
Well I was thinking more of the Nikola Tesla who used to hang out at Lady Sally’s after he died.
Fiver, if we include Gyro Gearloose, we’ll have to include
Gadget Hackwrench.
cool!