Dr. Schreber (Kiefer Sutherland) from Dark City.
Dr. Arliss Loveless _ Wild Wild West
Dr. Kynes – Planetologist in service of the Emperor on Dune
Dr. Wellington Yueh – Personal Physician to Duke Leto Atreides
Dr. to the Baron Harkonnen
Dr. Banner _ The Incredable Hulk.
The Rani – Biologist Evil Timelord banned for her research methods.
Debrose – Creator of the Daleks.
No love for Dr. Bunsen Honeydew!?!?!
Well, you know, there’s a reason for that. You see, the buddy of mine who works for Vandy is the reason why I BRIEFLY dated a chick who looked like Beaker, given that I like to rag him no end that her sister (whom he was dating for several months) looked like the Banjo Player from Deliverance, I don’t think we’ll see Dr. Honeydew make an appearance.
Davros.
Dr Who is filled with mad scientists, sadly most people would find them “too obscure”.
Gyro Gearloose- Ducktales
Doctor Doom-Fantastic Four (appearances in two movies, 2 FF cartoon series, guest spots on Spider-man cartoons)
Captain Nemo- AFAIK he designed the Nautilus, had plans for a colony on the seabed, and could build cybernetic limbs. Scientific knowledge+hatred of humanity+plans on building secret kingdom= Mad Scientist
Deadeles- Father of Icarus.
Dr Frankenfurter- He made a man with blonde hair and a tan. Frankie was just a sweet transvestite from transexual transylvania-huh-huh!
Dr Noonien Sung- Creator of the first working positronic brain
Professor Tillinghast- Built funky machine to see into different dimension and stimulate pineal gland. From From Beyond.
Professor Frink- flying motorcycle, self tapping shoes, machine for seeing the future, much, much more.
Proffessor Hubert Farnsworth- FTL starship drive, giant albino apes that shout “I Love You”, the what if machine, the fingerlonger, a hat that makes chimps geniuses, boxes that contain universes, a race of atomic supermen who play basket ball.
ftg
OTTOMH
Major Doctor Ghastly- From Evil Con Carne
Doctor Girlfriend- From The Venture Brothers
Samantha Carter-From Stargate SG1
Gadget Hackwrench-From Chip N Dale’s Rescue Rangers
Doctor Génessier kidnaps young women and surgically removes their faces in hopes of grafting the skin onto his hideously deformed daughter. This is all seen in more detail than you might care for, despite being made in 1959. If you haven’t seen Franju’s brilliant **Eyes Without a Face**, check it out–Criterion now has it on DVD.
Dr. Catheter (Christopher Lee) from Gremlins 2.
Thanks DocCathode.
BTW, you wouldn’t happen to be clinically “disturbed” as well as doctor would you? 
Dr. Moreau as in The Island of…
The Marlon Brando version would be great and you could use the South Park rip-off as well.
you want female mad scientists?
Jesse James Meets Frankenstein’s Daughter
Cinema’s original mad scientist - Dr. Caligari.
And as long as we’re talking about television as well, I’ll put a plug in for the hapless Dr. Julia Hoffman from “Dark Shadows.”
Steve Martin as Dr. Michael Hfuhruhurr, in The Man With Two Brains.
Dr. Alfred Brandon (Whit Bissell!), from I was a Teenage Werewolf, who gave us these immortal lines:
Also the name of the website, which is well worth checking out: