I took Imitrex once and thought I was going to need to call an ambulance. My blood pressure went through the roof and my arms went numb . . . scary stuff.
Vicodin and other codeine meds make me really sick when I have a migraine (they increase the nausea) as does Tylenol. I’m back to lying in bed with my head wrapped in ice when one of my tri-annual migraine fests hit.
We can be triplets! 
Topamax works quite well for me, but can cause odd side effects in some people.
(Okay, I haven’t tried leeches yet, but there have been times when I’d have been willing to try anything to get rid of the pain. And yes, LouisB, I understand perfectly what you said about fearing migraines.)
That odd sensation is how you know that the medicine is opening up the veins to shoot the RX to your brain. Perfectly normal odd sensation.
What kills me about imitrex self injections is trying to get everything good-to-go to give myself the shot when my brain is throbbing and I can barely open my eyes to the (natural) light in the bathroom and I am on the verge of puking. I have farked up a few needles because I didn’t screw it on properly and when I pull it out of the container I have had the medicine go off like a teen age boy watching Baywatch by himself.
YAY for being a Triplet! Who is the EVUL one?
Huh, I had that happen to me a few times. Once it did it with both doses in the one pack, and the next day I took it back to the pharmacy and complained - I thought it was defective. They gave me the number of GlaxxoSmith Klein, and when I called to complain, they sent me a coupon for one free pack.
Well, it’s not me. I’m sweet and innocent.
That is what all the EVUL ones say.
An update.
Friday afternoon, I went back to the doctor’s office and had a heart to heart chat with her nurse, who also suffers from migraine. The upshot is that the doctor has had a change of heart* and has now given me a prescription for Fiorinal #3; she has even authorized a few refills. I took the prescription straight to the pharmacy and learned that it can’t be refilled as written because the doctor didn’t include the instructions as to how I should take the medicine. I guess if she had written ‘take ten ever thirty minutes’ it would be okay. Anyway, now I have to wait until Monday (at least) before I can actually have the damn things.
However, the doctor won’t budge on the Butalbital/aspirin/caffeine Vs Butalbital/APAP/caffeine issue; I’m stuck with the former when I know from experience that the latter works better. Oh well, I guess you can’t win 'em all.
*The doctor either had a change of heart or forgot that she had decided against Fiorinal #3 in the first place; I get the impression that patients are largely out of sight, out of mind with her.