Another thread old enough to vote 
Unfortunately, the answer is “it depends”. The Neanderthal version of Mike Tyson wins 9/10. After all, it’s stronger and tougher, possibly enough so to make up for the lack of specialized training.
But is Tyson stronger than the average Neanderthal? In his prime he was certainly stronger than the average human. He also had, for a boxer, good defensive ability. The Neanderthal’s greater strength means less if it never hits Tyson.
So Tyson was very strong for a Homo Sapiens. He was probably at least as strong as a Neanderthal. They are estimated to have been maybe 20% stronger than a modern human but Tyson was probably stronger than that.
Mike Tyson was only 5’10" but Neanderthals averaged 5’5" so reach should go to Tyson.
Clearly training would favor Tyson.
If we are talking about an average Neanderthal then reach and weight could be an issue. Neanderthals were shorter than sapiens, and most wouldn’t have reached the heavyweight limit of 200 pounds.
Where they would have excelled would have been wrestling rather than boxing. They could have brought their superior strength to bear more easily. Many Neanderthal skeletons show fractures equivalent to those of rodeo performers, which has caused some scientists to speculate that they hunted by bull-dogging large animals to the ground. Someone who can pin a musk-ox wouldn’t have a problem with any modern human.
Tyson in his prime wasn’t just any modern human.
Of course. That’s what makes this even a discussion. Even with reach and size advantages, the average modern human wouldn’t have much chance against the strength and resiliency advantages of the average Neanderthal.
Tyson. The training. And I’m pretty sure he’s seen KO’ing a T-Rex in the opening of his Cartoon show.
Yeah but years of cartoons taught me that cavemen killed T-Rexes on a regular basis so they could eat giant spare rib dinners.
Fred Flintstone’s car made a mockery out of Newton, didn’t it?
The Flintstone car worked on the Laws of Yabba-Dabba-Dynamics.
We’ve probably had this discussion before but I wouldn’t even rank Tyson as the best heavyweight. There are a number of human fighters who would have given him quite a bit of trouble even when he was cleaning out the division at ages 20-22. Angelo Dundee observed early on that his fighting style and his height were made to order for a good boxer/puncher with a quality left jab, and the first guy to pose that challenge was Buster Douglas who, for one night, put it all together.