Ok, I exist to serve. Roseanne is off.
Nope, Maude had Adrienne Barbeau, certainly a hottie by contemporaneous community standards.
Oh yeah, a definite for the list.
And fangirls. Mmm.
If I might respectfully disagree… and all of course IMHO:
Julia Louis-Dreyfus is eye-candy (and may be a wonderful and appealing person, I have no idea).
Elaine Benes is unattractive. A deeply, deeply unattractive human being, in a “would I let my friend date her” sort of way. (Actually in a “would I wish her on my worst enemy” sort of way…) 
I remember everyone looking rumpled and tired all the time.
She had a last name?
So sayeth Wiki and IMDb. 
ETA: I’ll admit I may be biased against the show. I have a really adverse reaction to “NY neurotic”.
I’d like to mention Homicide: Life on the Streets. The beauty of young Kyle Secor & the hotness of Andre Braugher ruined the curve & kicked up the average hotness level. But, at the beginning, the rest of the cast was hardly pinup material. Richard Belzer? Ned Beatty? Yaphet Kotto?* Melissa Leo had a natural beauty but certainly didn’t flaunt it.
However, as the years went by & the old faces were replaced by young cuties, I think the overall quality of the show suffered.
- Wikipedia explains why Kotto could play a half-Sicilian with conviction:
Indeed she does. It’s mentioned several times throughout the series. Nothing of a secret, like Kramer’s first name.
No way Two and a Half Men can go on the list. Charlie Sheen and Jon Cryer are both serious eye candy.
They’re not that eye candy-ish are they? They both look like fairly normal people to me. But then again, I’m a straight male, so what do I know. 
I would also like to submit The Three Stooges.
I think this group is pretty fat and ugly. Definitely fat.
Gunsmoke for long-running lack of hotness, other than the prairie itself. Link
The original cast of Cheers wasn’t all that pretty, Sam & Diane’s opinions of themselves notwithstanding.
Oops you’re right, I’m sorry! I should’ve remembered Troy McClure SF from such threads as … well, this one.
At least Clooney didn’t have a full-on mullet on Roseanne, as I believe he did on Facts of Life. Clooney just had kind of a puffy front thing happening. Dead sexy to moi. And I’m not even a huge fan.
They have both been on “My List”* for years. To be able to watch them togther every week is pure nirvana.
*You know,your “celebrities you can do with impunity if the chance ever presents itself” list.
I’ll admit that Sheen does have a certain something about him, but his face is still pretty damn normal to me.
But then again I’m a fan of Kate Hudson and other such celebrites that people call Cookie Cutter Celebs. 
I’ve been watching this Australian soap opera from the 70s-80s about a woman’s prison called Prisoner:Cell Block H. I love the show but it has completely destroyed any fantasy I ever had about a women’s prison.
How about The Shield? Not the prettiest main cast ever seen and definitely the ugliest guest stars I’ve ever seen.
Vic Mackey: Bald and has a beer gut
Shane Vendrell: Ugly, buck toothed and racist to boot
Curtis Lemansky: Ok, Lem isn’t so bad
Ronnie Gardocki: Would be handsome if not for the imprint of a stove burner on his face
David Aceveda: Otherwise handsome man except he looks like he shaves with buckshot
Claudette Wyms: Sacrificed looks for coolness. I love Claudette but she’s ugly as hell
Danny Sofer: not bad but definitely not a Hollywood beauty
Julien Lowe: handsome
Dutch Wagenbach: nerdy appeal I suppose. But not leading man looks, that’s for sure
Corrine Mackey: cast in an act of nepotism, not for looks
Tina Hanlon: added in the fifth season to be eye candy. Insanely hot but only seen in civilian clothes about twice during the three seasons she was on