My first thought when I read the title. 80/90. I believe I read once about how so much traffic from all parts east and south pass through there to get past Lake Mich and parts N and W.
Add in that some part of it is ALWAYS under construction! 
But I do not know how it actually compares to other roads, such as near major ports.
Those are 3 different roads, no?
I must admit I don’t see those often at all. But damn, that highway is awash in regular tractor-trailers!
I hate those huge numbers of tractor-trailers on the highways firstly because they’re dangerous – not long ago someone was killed when an improperly secured trailer tire detached and crashed through the windshield of the car behind, and they have a habit of jackknifing and causing serious accidents and massive traffic backups. They also slow traffic, they block your vision of signage and other traffic, they can be hard to get around, and as an added bonus, they’re hard on the highways, especially when some truckers decide to haul overweight loads and take a chance that they won’t pass an open weigh station. In fact, flouting the rules on safety, maintenance, and load limits seems to be part of the culture embraced by too many truckers.
Gawd Chicago highways. At one point don’t those all converge into all the same road with the exception of the skyway? Anyway that entire stretch of multiple highways from Gary to the burbs is fraught with crazy drivers and menacing trucks.
When we want to chill on the drive downtown the skyway is the ticket, albeit no shoulders, rotten tolls industrial scenery but it’s less crazy imo than the freeway.
And I’d gladly pay my open tolls if I could navigate that frickin Byzantine Illinois tollway website with stacks of entry and exit points it’s a spaghetti bowl.
Here’s a vote for I-80 across Iowa and Nebraska. In particular, the stretch around Des Moines where I-80 shares the road with I-35 is a freaking nightmare.
After one time when we were coming back to Toronto on a Sunday afternoon, heading west on the 401 in heavy traffic, screaming along in what felt like bumper-to-bumper traffic at about 120 km/h, I started calling the 401 the “Evil Death Highway of Doom”.
I-84 through Oregon and Idaho has to be high on the list. It’s basically the only route (along with the train tracks on both sides of the Columbia Gorge) for goods brought into the Portland, Tacoma and Seattle ports to get out to the rest of the country. You haven’t had fun until you’ve whiteknuckled your way from Meacham to Baker City in a pouring snowstorm hemmed in by semis the whole way. You can try to use the left lane but it’s full of idiots who think AWD can cancel inertia. That’s not a fun drive and I don’t envy the truckers who have to drive it.