Oh, yeah, that’s a good one.
Also “Nightfall” by Asimov. The story is at this link - http://www.astro.sunysb.edu/fwalter/AST389/TEXTS/Nightfall.htm
I’ve only seen it the once, but given that I was literally sobbing in the theater doesn’t take away the impact.
Bing Bong in “Inside Out”.
It’s actually very reminiscent of the Toy Story 3 example. It’s not the act itself that gets me, it’s the moments leading up to it. When I realized what was going to happen and silently saying to myself “no no no” but seeing it happen anyway. God it’s just heartbreaking.
Honorable Mentions:
Griphook in the 7th Harry Potter Book, while taking in the Big 3 (plus Ginny) “So young to be fighting so many.” It’s my absolute favorite line in that entire series.
The sign scene in Love Actually. This is more sentimental because of an ex, but I couldn’t NOT cry every time I watched that.
Last but not least. The end of Shawshank Redemption when Red is talking about life after Andy leaves and simply says “…But most of all, I missed my friend.”
Neil Gaiman’s The High Cost of Living has a couple of moments. The conversation with the girl wearing the long gloves and the end, when Didi talks to God.
“It ended too soon.”
“It always does. That’s what gives it value.”
from Lord of the Rings: “Your father loves you, Faramir, and will remember it, ere the end.”
“What’s that you’re playing?”
“A little something of my own.”
"Stop it. You know what I want to hear.
“No, I don’t.”
“You played it for her… You can play it for me.”
“I don’t think I can remember…”
“lf she can stand it, I can. Play it.”
“Yes, boss…”
I’m a softie, so there have been of tear-inducing scenes already mentioned (I do want to re-read Watership Down, but not yet).
We were driving to Birmingham (UK) to see friends, and during last part of the journey I was listening to a recent BBC Radio adaptation of “The Snow Goose” (Paul Galico).
We arrived about 10 minutes before the end of the story, and stopped at a park. Eveyone else got out, but I sat in the car to hear the end, and it took another five minutes for my face to dry and for me to compose myself.
I also used half a box of tissues watching “Les Miserables” in the theater when it came out.
I wanted an easy way to re-add my contribution. My eyes keep tearing up here, for some reason.
Another one: “Dobby is a free elf!”
For me, it was Forrest saying goodbye to Jennie at her grave.
And the ending to Big Fish, for some reason, had me sobbing like a baby.
I read The Tale of Despereaux to my students every year. It’s a phenomenal children’s book, and I super recommend it especially to adults who grew up before it was written. Don’t ever see the movie.
In the final chapter, there is a paragraph about the relationship of a father to his daughter that chokes me up every time I read it. It’s short, elegant, beautiful.
Another read-aloud that gets me is The Man Who Walked Between the Towers, a picture book about Phillip Petit and his highwire journal between the under-construction Twin Towers. I read it every 9/11 to my students as a way to introduce a conversation about the day’s significance. The last page has a ghostly image of the Twin Towers and mentions, obliquely, that the towers are no longer there, but remain in memories such as this one. I never can read it without becoming all verklemt.
From the webcomic turned graphic novel, Digger: “Name is Ed!”
It’s still available online. It startshere.
+1 on “Have a catch”, Scrooged, (and just about any Christmas Carol–but especially Michael Caine w/the Muppets.)
Also the ending of ET, and when Zoey Deschanel gets the crowd singing in Elf.
I’m falling apart in my old age…
I don’t often agree with you, but Big Fish gets me, too. It came out just a little over 2 years after my own father died unexpectedly, and right after my grandfather (Dad’s dad) lost his battle with cancer. To the people that knew them, they were “larger than life” characters like Edward Bloom.
From ROTJ : You were right… you were right about me. Tell your sister…you were right.
Kicks the dust up in the room every time… sniff
There. Now it looks like he’s sleeping. 
Or when Luna is posting notices asking for her belongings to be returned, saying they hide them all the time.
By the hammer of Grabthar, by the Sons of Warvan, you shall be avenged.
Sorry if it’s been mentioned - I didn’t see it upthread- the last scene in* Brokeback Mountain.*Fuck me, that movie wore me out emotionally. When the lights came on all you could hear was the occasional sob in the sea of dead silence.
Girl Interrupted - The discovery of Daisy’s dead body, with End of the World playing in the background.
Lots of scenes from Requiem for a Dream but the one that comes to mind first is Marlon Wayans thinking about his mother.
All of the above are outstanding movies that I don’t think I will ever watch again.
“Take her to the moon for me.”
Absolutely crushing, and yet magnificent. If there’s a little girl you love, “Inside Out” kills you.
At the end of the movie Titanic when the camera pans out and we see hundreds of people frozen and floating in their life jackets.
I am literally incapable of reading his passage from The Velveteen Rabbit without tearing up. I’m doing it right now.
Also, the scene with the cat from Allegro Non Troppo. I won’t link it here. You’re welcome.
The Ending of AI, Artificial Intelligence, when Teddy is the only thing still “alive”, sitting patiently next to David for eternity. Sob.