JohnClay threads are magnetic.
If you mean The LAst Man on Earth I think it is the superior movie. Tiny budget but it has a better atmosphere and follows the book much better.
Welcome back?
Bolding mine.
Wow, you must have really hated the B&W one.
So the book was written 10 years after the movie based upon it was made? 
The Twilight Zone had more than one “last human(s) on Earth” episodes.
In addition to Burgess Meredith’s “Time Enough at Last,” there was an episode called "Two,"with Charles Bronson and Elizabeth Montgomery as the last survivors of a nuclear war. Bronson was an American soldier and Elizabeth was a Russian.
There was another post-apocalyptic episode called “The Old Man in the Cave.” A small band of war survivors has stayed alive by listening to instructions that their leader says come from a wise old man in a nearby cave. They have a lot of canned food that the old man has supposedly told them not to eat. Well, along comes a band of soldiers led by James Coburn. They demand to see the old man, and find out that “he” is a computer. They destroy the computer and get all but one of the survivors to chow down on the forbidden food… and they all die (the food WAS contaminated, just as the old man had tried to tell them).
This is a short story, not a TV show or movie (as far as I know, at least): Alfred Bester’s “Adam and No Eve.”
All life on Earth has been destroyed while a scientist was in space. He’s the only living creature left. But a voice (God? His crazed imagination?) keeps telling him to get to what’s left of the ocean. He finally makes it there, and realizes before dying that by getting to the ocean, he’s enabled the millions of microbes in his body to survive. And MAYBE those microbes will evolve once again into higher life forms.
Your thinking of the Omega Man. Charlton Heston. - The Omega Man (1971) - IMDb
No, he’s thinking of Vincent Price in The Last Man on Earth. The budget was low and some of it was a little cheesy, but on the whole, it was a decent effort. It was also MUCH closer to Matheson’s story than the other adaptations.
The trailer and the movie are both on Youtube.
There are a LOT of sf stories about this concept. There’s even an anthology
http://www.apocalypsebooks.com/last-man-on-earth/
There are fewer films and TV shows about a single last person or, more commonly, group of people (you really do need someone to talk to).
A lot of the obvious ones have been listed above
Five – from Arch Oboler, who gave us the Lights Out! radio show. This 1951 film has foive survivors of a nuclear holocaust
Target Earth – Five or so people left in an abandoned city being attacked by extraterrestrial; robots. Surprisingly good far from 1954. They’re not the last people on earth, but for most of the film they might as well be
The Bubble (AKA THe Fantastic Invasion of Planet Earth) – a couple stumbles into a town where they and the remaining inhabitants are trapped by a giant transparent bubble and – heyyyyy isn’t there a Stephen King novel and miniseries about this? (Couldn’t be - he NEVER steals ideas!). Another Arch Oboler confection, this time from 1966. In 3D! (really – I saw it that way)
Again, not the last people on earth, but if you’re under a doome, does it make a difference?
Robot Monster – I know, I know. It’s an awful film. But it DOES feature a handful of people left alive when everyone else is gone, threatened by the gorilla-suited space-helmeted Ro-Man. Also in 3D, not that it helps, although it does explain the use of the Bubble Machine. With music by Elmer Bernstein!!!
The Day the World EndedRoger Corman does the post-nuclear holocaust in this 1955 film that features a handful of survivors in a surprisingl;y untoucherd suburban house. A Telepathic three-eyed four-limbed mutant wants the girl (a typ[ical Paul Blaisdell monster suit), but , like lots of monsters in movies, it dissolves in water.
Chosen Survivors – the survivors of the nuclear holocaust are menaced in their underground bunker by rabid vampire bats. From 1974, with Jackie Cooper, Bradford Dillman, Pedro Armanderiz, Jr., and other actors who should have known better. Corman’s The Day the World Ended is better.
Key and Peele’s Last Man on Earth is a short subject film, but it explores the essence of the genre with great depth of feeling.
There are several anthologies. It’s sort of my hobby.
That company that makes low-budget movies timed to come out with blockbusters also made I am Omega to coincide with the release of Smith’s I am Legend.
At the end of the Japanese version of Ju-on/The Grudge, it is implied that the ghost killed everyone.
1964’s Last Man on Earth is indeed based on I am Legend; the novel was published in 1954.
I <3 Richard Matheson and have collected original copies of his short story collections and novels over the years.
As far as short-story anthologies go, in addition to the above listed Last Man on Earth book, (not the movie directly above) there are:
Armageddons featuring Frederick Pohl’s “Fermi and Frost”
The End of the World featuring Phillip Dick’s "Impostor*
Catastrophes featuring Fritz Leiber’s “A Pail of Air”
After the Fall featuring Harry Harrison’s “The Day After the End of the World”
Note, most of these stories are actually ‘end of the world’ stories.
*Which I discovered well after I read it that it was made into the Gary Sinise movie of the same name.
After the Fall is not merely a collection of “End of the World” stories – it’s a collection of upbeat end-of-the-world stories, edited by Robert Sheckley. Definitely something to add to your collection. AQs such, there aren’t a lot of “Gee I’m the Last Guy Left” stories. But it does contain one of my facvorites – Philip Jose Farmer’s The Making of Revelation, Part I, in which God gets Cecil B. deMille to produce and direct Armageddon. deMille, in turn, gets Harlan Ellison to script it, because Ellison is the only writer who’s not afraid to argue with God. In the end, God gets fed up with Ellison and replaces him with a hack from Peopria.
How about Fukkatsu no Hi (“Virus” in English) from 1980. It had the largest budget ever for a Japanese movie when it came out, although I remember it being mostly in English. Surprisingly good. Much of the story is set at a research base in Antarctica and Edward James Olmos is part of the cast.