IIRC each quadrant was filmed in one take as well which meant that they all had to be filmed at the same time since some of the ‘quadrants’ ran into each other at certain times in the movie. I also remember it not being a very good movie, just neat to watch.
Next up: Rope.
Pulp Fiction.
Cool timeline of cgi movies and firsts
Tim Burton films
Rudolph the Red-Nosed Reindeer, TV movie
The Lost World, 1925
What was that silent film a couple years ago with the dog?
Wow. Did not know that. The media at the time made a big deal about what a new concept it was, but those two plots & methods are almost identical.
The Bear
Fantasia
Prospero’s Books – easily the weirdest version of The Tempest you’ll ever see. A completely different experience from “ordinary” film-making.
Santa Sangre and/or any of Alejandro Jodorowsky’s films.
Immortal, a film by renowned artist/storyteller Enki Bilal.
Scott Pilgrim vs. the World had a very cool, unique style.
So did Bunraku, a terrific film that no one has seen.
The Wizard of Speed and Time was amazing.
I loved The American Astronaut.
Several documentaries come to mind, but I’ll only mention In the Realms of the Unreal, which was beautiful and weird and amazing, both in story and in the telling.
“Bram Stoker’s Dracula” (FF Coppola, 1992). Technically, it was nothing new, but he threw in everything plus the kitchen sink.
What Dreams May Come was visually stunning and unique, for which it rightly won the Visual Effects Oscar despite the story not making a lick of sense.
Trivia note: My stepdad’s daughter, who he’s been estranged from since birth, was part of the visual effects design team.
A mesmerizing film.
Ralph Bakshi’s version of theLord of the Ringshas been much maligned, but it certainly had a unique style.
Who Framed Roger Rabbit broke the mold as far as integrating live action and animation.
Preceded by Waking Life.
The Artist. But it wasn’t anything new. The filmmakers were intentionally invoking old techniques.
I think I remember that, somewhere between 2000 and 2002. It was the ultimate uncanny valley movie, with all cgi “actors” that looked kinda sorta “real.” I can’t remember the name of it, though.
Unless you mean Sky Captain and the World of Tomorrow?
I’ve never heard of Cannibal Holocaust, but the gimmick of The Blair Witch Project is that it was a documentary supposedly compiled of found/recovered footage taken by the subjects; that’s the trend it started. Is that was CH did, or is it just Spinal Tap with zombies?
from the link offered previously:
I can think of a lot of movies that have unique visual styles, but most of them suck. For example, “Zachariah.” The sixties and seventies were a period of great visual experimentation, and frequent failure.
And from that time period - Grand Prix. Incredible racing visuals and sounds, and brilliant use of split-screen and multiple checkerboard-type images not just in the opening sequence but throughout the film, and all this long before the use of in-car cameras had become a normal part of motor racing coverage. Monaco at speed from the drivers’ eye level is still dazzling. 
Rent the film if you can, or check out the first few minutes here starting at about 15 seconds in, and ignore the totally unnecessary added “music” that someone foolishly thought was more interesting than the actual soundtrack. In the film there was no music during this sequence at all, just the sounds of cars at speed. On a giant screen and in a theater that had what for the time was a state of the art sound system, it was guaranteed to get your adreniline pumping.
The storyline stunk, but the racing footage more than made up for it.
The 1992 film Toys certainly fits “unusual” with its odd plot, characters and Magritte-like scenery. I loved Joan Cusack in this film.
Another strange movie starring Juliette Lewis is Meet the Hollowheads. It’s rated under 5 on IMDB, but worth watching for the sheer bizarreness.
I thought of that one too at first, but there were actually lots of previous live/animated movies like Mary Poppins, Incredible Mr Limpet, Xanadu, and many others.
The Matrix is an incredibly dumb movie. But such style!
I’ll add two more suggestions - Pleasantville, and anything by Tim Burton.