I gotta chime in here. I was born, raised and educated in California, then moved to Seattle for work. I only lasted three years before fleeing back to wonderfully sunny California.
Jobs- It’s been more than three years since I’ve left, so I can’t really say much about the job market. I do know that the health science fields are doing well there- maybe a biotech firm could use your skills?
Weather- The short and overcast winter days really got to my wife and I. I, too, was looking forward to experiencing some more changeable weather. However, by the middle of our second winter there, the novelty wore thin and my mood turned gloomy like the weather. Summers are nice, though too short.
Crime- I came from L.A. and lived in neighborhoods there worse than any I saw in Seattle. True, like most any major city, there’s going to be places you don’t wander around in at the middle of the night (Rainer Ave comes to mind), but Seattle seemed a relatively safe city.
Housing- Before moving to Seattle, I had to make two house-hunting trips before I found a adequate place for a family of three to live. At the time, decent rentals were hard to come by. We finally settled on a newish apartment complex off Aurora and N 130th (Bitter Lake neighborhood). It was an OK area, but the commute sucked. As I couldn’t get parking at my workplace downtown, I had to ride the bus- a 10 mile trip that often took 90 minutes to complete. After 6 months of putting up with this, I finally had to practically threaten a terrorist act to get my employer’s permission to park in their lot. When our lease ran out after the first year, we lucked out and through a friend of a friend deal, we rented a wonderful little house in Bellevue with a huge yard. Unfortunately, the commute into/out of downtown on the I-90 bridge could be brutal, but nothing an LA boy hasn’t dealt with before.
Both of these locales really don’t meet your criteria for a place with or near good nightlife. I had a couple of friends that lived in the Wallingford area- it has it’s own share of nice places to hang out in and it’s located between the University area and Fremont and their assorted nightlife attractions. It may be a bit pricey, though. A quick search of seattletimes.com shows small rentals going for about $750 and up.
Getting there- Definitely consider the southern route over to California, then shoot on up I-5. The mountain passes on I-5 (the Grapevine through the Tehachapi Mnts north of LA and through the Siskiyou Mtns of far northern California) are less likely to be closed due to snow than the Rockies and Cascades.
Good luck!