Name the first five female Mad Scientists that come to mind...

Cafe Society
21

Boy, nobody remembers Lady Frankenstein from the wonderfully awful film of the same name? Or the lady from The Atomic Brain?

There’s also one that I wrote for an unpublished story – FrankHolstein. She’s a Mad Cow Scientist who tries to create a Bull from parts she got from the butcher store, sewn together. She’s assisted by her twisted hunchbacked donkey assistant, Eeyore.

22

Would Dr. Girlfriend count?

23

The old woman in Minority Report with the deadly plants.

24

Helen Narbon, Narbonic
Agatha Heterodyne, Girl Genius
Helena G. Wells, Warehouse 13
Helen Cutter, Primeval
Princess Bubblegum, Adventure Time

Lots of Helens on my list, for some reason.

25

DNAmy from Kim Possible
Delia Surridge from V for Vendetta
Maggie Walsh from Buffy The Vampire Slayer
Beverly Hofsteder from The Big Bang Theory

26

Would Cosima from “Orphan Black” count? I’d guess she was more of a quirky, eccentric scientist rather than mad scientist; but she was nutty enough to be pro-neolutionist (at least until the whole “intellectual property” issue came up.)

Anyway,
Doctor Cyber

Ruby Thursday

The Rani

Dr. Janice Lester

27

“Ruby, now with a much smaller head, later participates in the plan to gain her ally Chondu a new body.”

I love comic books.

28

The only one that came to mind for me (despite the fact that I read Girl Genius three times a week - bad, bad brain!) was Veronica Cale, an enemy of Wonder Woman before the “new 52” reboot.

29

Dr. Maggie Walsh, from Buffy the Vampire Slayer.

Maria Frankenstein, from Jesse James Meets Frankenstein’s Daughter.

30

Emmaline Cayley, from the series The Mad Misadventures of Emmaline and Rubberbones, by Howard Whitehouse.

31

You can double the Helen Narbons in Narbonic. There was the original and the beta.

32

Nice! One more, and we can compile an all-Helen list of mad scientists!

33

Five Helens agree…

34

Well the first person to come to mind was Original Wonder Woman. She had a snazzy little place called Transformation Island where female criminals were reformed by being put in bondage … lots and lots and lots of bondage … and then lovingly dominated by women dressed up as drum majorettes. They learned to love their chains. Oh, we are talking Mad Scientist City here!

The other one I can think of that has not been mentioned yet is Dr. Carol Marcus of Star Trek, inventor of the Genesis Device.

35

…they’ll rule the day they laughed me out of the academy!

36

Not looking at others first:

  1. SHODAN, from the first System Shock (technically not female, but voiced by a woman)
  2. GladOS, from Portal (see above)
  3. Franny K. Stein, the protagonist of the eponymous series of children’s books
  4. Matriarch Benezia, from Mass Effect
  5. Marie Curie to round out the list–hey, she managed to kill herself with her research into strange otherworldly energies, and what says “mad scientist” more than investigating things Woman Was Not Meant to Know? [oops–without, apparently, looking at the OP either–sorry!]
37

Margaret Thatcher?

38

Mad, but not a scientist.

39

Rhona Burchill, the Ultimates version of the Mad Thinker.

40

Elsa Kast from Splice would qualify in the “playing God” department and general lack of good judgement (i.e. “mad”)