Professor Fate is from “The Great Race”
I’ll add my all-time fave villian:
Zakalwe
A few more
Visual media :
The Evil Midnight Bomber What Bombs at Midnight
Evil
Vermithrax
Non-visual media :
Hob, The Serpent’s Son
The Abomination, Lord of the Gulfs
The Dominator
The Burning Man
Vermithrax – Dragonslayer
Yep !
I’ll replace that with Hexadecimal.
He was either the CEO or the president of special projects of the LA branch of Wolfram and Hart (Angel.)
The Evil Midnight Bomber What Bombs at Midnight id from The Tick.
And, and he’s stickin’ it TO THE MAN, BABY! YEAH!
from The Tick (the animated series)
Damn.
I thought people would get that, but he was just too cool not to mention. 
Reboot!
Norman “EVERYONE!” Stansfield; from Leon
Tuco; The Good, Bad, and the Ugly.
Well done Dopers, I think the only villains from my initial list that haven’t yet been identified are :-
William Cutting
Hando
Malachy
Howard Saint
Brother Justin
Silas Greenback
Mr. Barlow
I can identify :-
Count Adamar - A Knight’s Tale
Damon “That hits the spot” Killian - The Running Man
P.S. Sorry folks, “Santino” is actually from a novel not a movie or T.V. :smack:
But here are a few more :-
Ray Barbone
Sutter Kaine
Major Konig
Lestat De Lioncourt
Captain Howdy
John
Grand Moff Tarkin
Beebop & Rocksteady
Gabriel
Guiles Gisbourne
H.A.L.
David
Ellis Dewalt
Oswald Cobblepot
Dorian Tyrell
Gusto
Teabag
Top Dollar
Dr. Kelso
Lord Melchitt
Major Konig - Enemy at the Gates
Lestat De Lioncourt - Interview with the Vampire
Grand Moff Tarkin - Star Wars
Beebop & Rocksteady - Teenage Mutant Ninja Turtles
Gabriel - More than one, I’d wager. Constantine?
Guiles Gisbourne - Robin Hood. It’s Guy of, not Guiles, isn’t it?
H.A.L. - 2001
Ellis Dewalt - Beverly Hills Cop III
Oswald Cobblepot - Batman
Dorian Tyrell - The Mask
Dr. Kelso - Scrubs
Lord Melchitt - Black Adder
Silas Greenback is the archenemy of DANGERMOUSE
The Penguin, to be precise.
In all cases, I named where the villain was from, not another name for the villain. I also didn’t mean that Grand Moff Tarkin was called Star Wars, or that Ellis DeWalt was called Beverly Hills Cop III, or that Bebop and Rocksteady were collectively known as the Teenage Mutant Ninja Turtles.
Would this Santino be from Interview With The Vampire, then?
Gabriel- If we’re talking archangels here, I’d take this to be Christopher Walken’s over the top, ass-kicking, leather pants wearing Gabriel from The Prophecy.
Top “Caw, caw, bang, fuck I’m dead!” Dollar- The Crow
How about these (probably easy) ones:
Lord Kane
Ricardo Diaz
Officer Tenpenny
Papa Joe
GTA Vice City; “Good NIGHT, Mr Diaz.” < BLAM >
Corrupt cop from GTA San Andreas.
That would be Santiago. There is a character called Santino, but he doesn’t appear til later.
Mr. Barlow is from Salem’s Lot.
Ray Barbone is from Get Shorty.
Is Malachy supposed to be Malachi? If so, I think that is from The Children of the Corn.
Reposting mine that didn’t get answered (at least one of which I thought’d be easy):
Cassandra Blair
Jason Wyngarde
Marco Dane
And I’ll throw out a few more:
Eros
Thascales (actually, this is a pseudonym used by a villain more popularly known by another name)
Jame Gumb
Joe Chill
Vitus Werdegast
The Duke - Boondock Saints
My addition:
Conrad Detweiler
John G