If the antivenom production takes 5 minutes and venom is used to heal the body whereas antipoison is used to inactivate the poison making it safe to be excreted and takes 7 minutes to form and there is a small chance of anaphylaxis then a simple formula can be used.
Here it is:
of poison and venom cases per year - (# of poison and venom cases per year * chance of anaphylaxis(assuming everyone that gets anaphylaxis deserves to die)) = # of survivors
So if there are 1,000,000 humanoids in a given area of civilization and all humanoids survive animal borne illnesses and there is a 1% chance of anaphylaxis with bee stings and there are 10,000,000 bees and the chance of a bee sting is anywhere from 10-15% that is 1000-1500 deaths from anaphylaxis from bee stings.
Likely all the humanoids with anaphylaxis have bad genes and so over years and years anaphylaxis is selected against.
This would cause the immune system of the humanoids to be more resistant to IgE formation since IgE is what causes allergies and anaphylaxis but the immune system is trying to make IgG.
A few thousand deaths is low in a population of a million or more.
But would this be feasible for 1000-1500 of the humanoids that are stung by a bee in a population of 1,000,000 to get anaphylaxis and die given that anaphylaxis is unlikely and the venom is going to be digested anyway?