Phoebe or George (they are both whining sex addicts. If George had money, he would be Karen).
ROFLMAOSCOK 
Replace Robocop with the Terminator
Replace Captain Janeway ( Voyager ) with Susan Ivanova ( Babylon 5 )
Replace Mr Spock with Data, and visa-versa
Replace Odo ( Deep Space Nine ) with the T-1000 from Terminator 2 ( both liquid )
Replace the T-1000 with Inque from the Batman Beyond cartoon ( both shapechanging assassins )
Replace Luke Skywalker with Samurai Jack ( both noble swordfighters )
Replace Bart Simpson with Eric Cartman
Replace cast of Sex in the City with cast of Desperate Housewives
Replace Det. Bensen with Det. Lacey
Replace Battlestar Galactica Six with Tripping the Rift Six
Replace Krusty the Clown with Obnoxio the Clown
Replace the Borg with the Cybermen
Replace Marge Simpson with June Cleaver
Replace Wesley Crusher with anybody
but really: replace Wesley with the kid from Lost in Space
Replace Marvin with C-3PO
Swap Garfield and Sebastian
Swap Jim Anderson for Dan Conner
But what about Seven of Nine? :eek:
Swap Josh (the Wonder Years) with Screech
Swap Principal Sneider (Buffy) with Principal Woodman (Kotter)
Swap Homer Simpson with Fred MacMurray’s character from My Three Sons
Swap Brett Butler’s Grace with Donna Reed
Swap Capt. Kirk for Capt. Binghamton (McHale’s Navy)
Swap Beaver Cleaver for Christopher Titus*
*I could do this all day.
anyrosep, may I call your attention to:
It’s post #13 in the FAQ - guidelines for Posting at the SDMB thread in ATMB.
All in the Family: Replace Edith “dingbat” Bunker with Marie Barron from Everybody Loves Raymond.
Everybody Loves Raymond: Replace Marie Barron with Livia Soprano from the Sopranoes.
the Sopranoes: Replace Livia Soprano with Endora from Bewitched.
Bewitched: Replace Endora with Edith “dingbat” Bunker.
Seinfeld: Replace George Costanza with Larry David from "Curb Your Enthus…wait, that wouldn’t change a thing.
Gilligan’s Island:
Replace the Professor with Professor Frink and the Skipper with Zap Brannigan
Lost in Space:
Replace the Robot with Bender
Star Trek:
Replace Dr. McCoy with Dr. Szell (from Marathon Man)
swap Wolverine for Fezzig (Princess Bride)
Swap Dan Fielding for Denny Crane
Swap Remmington Steele for James Bo… oh wait, isn’t that how he got the job in the first place?
I like the first two suggestions, but…
Replace Dr. McCoy with Dr. Zoidberg.
“Damnit, Jim, I’m a doctor, not a cephalopod! Woo-woo-woo!”
Maybe Dr. Szell would be better in the alternate Spock-with-a-goatee universe.
Swap Mr French with Geoffrey
I don’t know if this qualifies, but replace Judge Judy (or Mulian, or Wapner, or any of them) with Harold T Stone
what about swapping the Sex and the City girls for the cast of Golden Girls
Replace Marshal Matt Dillon (“Gunsmoke”) with Marshal Sam McCloud (“McCloud”).
It will be fun to see how McCloud and Chester get along.
On his ship, Mal is in charge. Duh.