Fake Punt. They’ll never see it coming.
Even better - a real punt.
Misdirection. Fake to fullback dive and pitchout to halfback around end.
::runs the naked bootleg through the thread::
Put my 9 best blockers on the line, hand off to my strongest running back, and have him pick whatever gap looks the most promising and dive straight ahead.
The question is of course impossible to answer without knowing at the very least your own team’s personnel. That said, QB sneak is the play that, even if it doesn’t work, you can probably most easily defend your call.
QB sneak. Brees does a terrific one that almost always works, where he takes the snap and leaps forward over the center’s head with the ball thrust forward – all the ball has to do is break the plane for an instant, and it’s a TD. Very hard to defend since the D has to react to Brees and the C, who move very fast.
Hand off to Marshawn Lynch
Kick it hard enough that it goes into orbit and passes through the uprights twice, for two field goals.
I’d exploit a forgotten sub-sub-paragraph of the rulebook to allow our talking mule to kick a field goal.
Do I have Gronk? I’m throwing it to Gronk.
OPI, game over. 
Yeah, I meant the clock is stopped (maybe previous play was an incomplete pass, or penalty). You have plenty of time to make a decision, you can also call a timeout; there’s a good chance the opposing defense will call one of their own, too.
Hey put some pants on!
That should work. Patriots have a great play where they pick the defense with another receiver and then throw it to Gronk. Refs never call it.
My contribution: Flea flicker, statue of liberty, reverse, WR option pass, hook and lateral. Worth at least 6 points every time.
Or fullback in the flat. Whichever fits the situation.
Before Gronk, they’d run it with Mike Vrabel, after he reported eligible. Ten career receptions, every single one a 1-yard touchdown.
I formation with a fullback and tailback.
Fake handoff to tailback up the middle.
Roll out and toss to wide open receiver.
Or put a defensive lineman in at fullback, put it in his gut, and have him dive forward.
Tell the nose tackle “Hey, your shoelace is untied”, and while he’s looking down, run right past him.
The odd thing was that defensive coordinators never seemed to notice or catch on to it. Even when it happened in the SUPER BOWL.