**Marie Antoinette[/V]
Eleonore Hirt played her in 1960 and 1982 (22 years apart!)
http://us.imdb.com/name/nm0386711/
**Suzanne Bianchetti seems to have played her three times over seven years:
Dominique Bresnehard did Louis XVI twice, seven years apart:
http://us.imdb.com/name/nm0078712/
Gilbert Bokanowaski played him three times in two years. I don’t kniow if it’s related or not:
Lowell Gilmore somehow got to be Pontius Pilate three separate times:
Lowell Gilmore somehow got to be Pontius Pilate three separate times:
http://us.imdb.com/name/nm0319557/
Robert Hardy (Cornelius Fudge from Harry Potter!) plated Pilate twice, thirty years apart!:
http://us.imdb.com/name/nm0362735/
I know it’s not quite the same thing, but Martin Sheen apparently seems rather Presidential to casting directors, as he has quite a few roles as either fictional or real Presidents and/or Vice Presidents, including:
The West Wing … President Josiah “Jed” Bartlet
Family Attraction … President
Medusa’s Child … President (U.S.)
The American President … Vice President A.J. MacInerney
Kennedy … John F. Kennedy
Barry Bostwick has played George Washington twice; in George Washington II: The Forging of a Nation (1986) and George Washington (1984).
Then there’s Joseph Kilgour, who played our founding father 4 times; The Battle Cry of Peace (1915), The Dawn of Freedom (1916), Washington Under the American Flag (1909) and Washington Under the British Flag (1909).
Alan Mowbray played him 3 times; Alexander Hamilton (1931), The Phantom President (1932) and Where Do We Go from Here? (1945), as did Howard St. John in La Fayette (1962), Our American Heritage: The Secret Rebel (1961) and The Patriots (1963), and as did William Worthington in Can This Be Dixie? (1936), Marry the Girl (1937) and The Spy (1914).
I’m sure this one doesn’t count – Douglas Wilmer played Sherlock Holmes in the series "Sherlock Holmes and the TV series “Detective”, all in 1964-5. He also played him in The Adventures of Sherlock Holmes’ Smarter Brother, but almost certainly because of his earlier roles (which were probably related)
Ah, you know what I meant. 
However, in 1939, he played the part in Fox’s The Adventures of Sherlock Holmes, and The Hound of the Baskervilles.
1942-1946
Twelve films were then made. He also played the part on multiple different radio show, in many different series. as well as on tv, for example in 5/30/1950 “Sherlock Holmes” (NBC Showcase), or in 5/26/1953 “The Adventure of the Black Baronet,” as Sherlock Holmes (Suspense, CBS)http://www.basilrathbone.net/
Also, according to the very untrustworthy sources on imdb, his voice was sampled for the part of Sherlock Holmes in the film The Great Mouse Detective
Charlton Heston played Andrew Jackson in two different films. He also played Sir Thomas More in a television movie, and several times on stage.
James Cagney played George M. Cohan in 2 movies and on Broadway.
The Seven Little Foys (1955)
Yankee Doodle Dandy (1942)
Ian Hart portrayed John Lennon in 2 films: **Backbeat ** (1994) and **The Hours and the Times ** (1991).
Dig this: William Devane played President John F. Kennedy in **The Missiles of October ** (1974) and 18 years later played his father-in-law “Black Jack” Bouvier in **A Woman Named Jackie ** (1991).
Jerry Haleva played Saddam Hussein 5 times.
Nitpick - in The Adams Chronicles he played John Quincy Adams. George Grizzard played John Adams.
Martin Sheen also played brother Bobby Kennedy in Missiles of October
Holm also played Jack the Ripper in From Hell.
If we’re including “historical characters” who are still alive, I’ll nominate Jeannette Charles (picture here, IMDB filmography here), who has played Queen Elizabeth II in at least ten movies and TV shows (and, I suspect, many more that don’t rate an IMDB Entry).
Sir Anthony Hopkins has played:
Richard I in The Lion in Winter
Captain Bligh in The Bounty
Hitler in The Bunker
Dr Frederick Treves in The Elephant Man
Daniel Webster in *The Devil and Daniel Webster * (still unreleased)
John Quincy Adams in Amistad
Ptolemy in Alexander
Col. John Frost in A Bridge Too Far
Dr. Kellogg in The Road to Wellville
Guy Burgess in Blunt
Nixon in Nixon
C. S. Lewis in Shadowlands
Paul of Tarsus in Peter and Paul
David Lloyd Geoge in *Young Winston * and “The Edwardians”
Yitzhak Rabin in Victory at Entebbe
Charles Dickens in The Great Inimtable Mr. Dickens
Picasso in Surviving Picasso
Danton in *Danton * (1970)
Edward Hermann has played FDR at least three times and it’s the first thing I think of whenever I see him.
Stephen Fry played Oscar Wilde in the (imo) excellent movie, in an episode of the short lived western Ned Blessing, in several audio recordings and on-stage.
Though nowhere near as well as Glenda Jackson, Bette Davis played Elizabeth I in two movies and on-stage. Judith Anderson also played her several times on screen and on stage (and with Charlton Heston caused one of the weirder stage couplings of all time as Elizabeth and Essex).
I’m fairly confident that the character AJ MacInerney was not the vice president. IMDB doesn’t say if he had a title, but his actions in the movie were more like a Chief of Staff (like Leo on “The West Wing”).
One: The VP doesn’t spend anywhere as much time at the White House that AJ did.
Two: The VP is rarely if ever as involved in the policy details of the administration.
Three: This exchange from the movie:*
President Andrew Shepherd: Is the view pretty good from the cheap seats?
A.J.: What?
President Andrew Shepherd: Because it occurs to me that it twenty five years, why have I never seen YOUR name on a ballot? Why A.J.? Whare are you always one step behind ME?
A.J.: Because if I wasn’t, you’d be the most popular history teacher at the University of Wisconsin!
President Andrew Shepherd: Fuck you! *
AJ’s never been on a ballot; i.e., he’s never run for an office, even VP.
[QUOTE=Shayna]
I know it’s not quite the same thing, but Martin Sheen apparently seems rather Presidential to casting directors, as he has quite a few roles as either fictional or real Presidents and/or Vice Presidents, including:
The West Wing … President Josiah “Jed” Bartlet
Family Attraction … President
Medusa’s Child … President (U.S.)
The American President … Vice President A.J. MacInerney
Kennedy … John F. Kennedy
He also played the evil president predicted to start WW III by Christopher Walken in “The Dead Zone”.
[QUOTE=MikeTheTiger]
Make that “presidential candidate”. The future envisioned by Walken was that he would start WW III if elected.