Provigil

And now for something totally different.

I read an article on a drug called Provigil in Reader’s Digest today. Originally developed to treat narcolepsy, others use it to remain awake, alert, and aware during the day.

Has anyone here used it? Any anecdotal evidence as to its effects?

Is there any medical-type person here who can explain the pros and cons of such a drug?

I’m considering using it since I have a problem with sleep and sleepiness - too much of it, really. Maybe it’s sleep debt. In any case, I need to use a caffein pill at least once or twice a week, just to keep awake and alert at work. (Could also be high blood sugar levels.) I’m hoping, from what I have heard about it, it will keep me active and awake, which would help me be more active (and lose weight) and actually accomplish the various tasks that I have wanted to finish for some time.

Danke!

WRS

HAH! I had no idea what the word “provigil” meant. I had to read it several times to make sure that I wasn’t just misreading some normal word. Once I was sure that I was actually reading it correctly, I thought, “That’s just got to be the name of a drug.”

And I was right!

I eagerly await the commercials showing people playing tennis, reading to their grandchildren, and singing in a gospel choir. “Ask your doctor about Provigil today!”

I’ve tried Provigil when I was severely depressed and couldn’t stay awake. It didn’t do anything for me at all, but your case is different, so it might work for you.

If the cause of your lethargy was pinned down, the right cure might suggest itself.

You should see your doctor and get his/her professional opinion. Sleep apnea, for example, can cause daytime sleepiness, but it’s just one of many possibilities. In any case, it’s best to treat the causes, not the symptoms. See your doctor.

Correct me if I’m wrong, but I thought your average caffeine pill is the same as one cup of coffee. If that’s the only caffeine you get, that doesn’t sound excessive to me.

The manufacturer has a web site describing its usual uses. What’s gotten some publicity recently is that people have used it to stay awake and functioning for long periods of time–24 hours or more–or to adapt to rotating shifts. It also apparently is not a stimulant, in the traditional sense, and doesn’t have the side effects of caffeine, amphetamines, etc. The military has apparently taken an interest in whether it might be useful for troops and pilots.

I would also like to read about the experiences occasional users may have had, say for studying the week before college exams, or finishing a major work project on deadline.

http://www.dailyfreepress.com/news/2002/09/25/News/New-Pill.Provigil.Allows.For.Less.Sleep.More.Work-281318.shtml
http://www.provigil.com/patient/home.aspx
http://www.modafinil.com
http://www.pslgroup.com/dg/1581ce.htm

I take 200 mg of provigil upon awakening every day. They were prescribed for me by my psychiatrist because I was sleeping too much during the daytime – either because of depression or because of the medication I take for depression. They work well for me and I have a little bit more energy.

I call them my “fighter pilot pills” because that’s what the doc said they are used for. (He also mentioned their original use in combating narcolepsy.)

I have had no side effects.

They are expensive.

If you are getting plenty of sleep at night and still nodding off during the daytime, I would think that you would want to find out the cause of your sleepiness.

You mentioned the need to lose weight. Have you gained weight recently? If you have a compulsive eating problem, you might want to talk with your physician about using topamax. It has completely gotten my mind off of food. (It’s also expensive.)

I am not a physician.

WeRSauron:

Provigil is an “awareness drug” with CNS stimulating characteristics much like amphetamines such as Ritalin; but the mechanisms are different. It is FDA approved for the treatment of narcolepsy, ADHD and certain forms of obesity. I don’t know how old you are, but there are important considerations with age, and especially hepatic and renal function. Metablolism of the drug is affected by age, making dosage adjustments compulsory. Also, if you have hepatic function deficiency due to age or disease, this will also affect your dosage. If you have renal function deficiency, you would probably have been prescribed something else. So I assume you are relatively healthy and young.

Your primary concern, of course, is “what can this chemical do the biologicalness of my body?” As with any foreign chemical you introduce into your body, it can have varied and pronounced effects. Any effect the drug has related to you can be totally different and contrary to someone else. Any other chemicals introduced concomitantly into your body (especially alcohol or any other medication you may be taking) can potentiate any or all of the effects.

Cardiovascular effects can include chest pain, heart palpitations and shortness of breath.

CNS effects can include visual and auditory hallucinations and insomnia (of course). Provigil has a slight potential for chemical dependecy. For this reason, the pharmaceutical industry “controls” Provigil, much like Morphine but to a much lesser degree. You have to sign for the drug to pick it up from the pharmacy and, like all prescription medications, you cannont share it with anyone.

These are the more common effects. To list them all would be nearly impossible in this forum. I say “more common,” but to assuage any anxiety, if only one out of 10 billion patients taking Provigil report a perceived side effect, the drug manufacturer has to list it as a possibility with everyone. So even though these are the most common effects, they may not be (and are not) common overall. In fact, Provigil is well tolerated overall. The most prominent effects are the ones true with almost any medication someone takes, including head ache, nausea, vomiting, diarrhea, etc. Heck, these are the most common side effects of waking up everyday. And, as with any medication, if you are now or, in the future, become pregnant (I cannot determine sex from your screen name) see your physician immediately. In short, the benefits do outweigh the disadvantages…for most. You must take the drug to know how it will effect you; but overall, most people have no major problems with Provigil and enjoy the benefits it produces.

The most important item, however, is to talk to your healthcare professionals. I know the purpose and function of SDMB, and I understand why you inquired herein; but it has its limits. The best information you can attain will come from both your physician and pharmacist. Each will have different and relevent information for you. They will also know relevent clinical information about you which you cannot find here or on any website. The info you get from a website, or even here, can be from some crackpot who wants to be aggresively helpful and actually know very little to nothing. I am a recent PharmD graduate, and have a fair bit of knowledge and resources available to me; but you have know way of knowing that.

I don’t know for how long you plan on taking Topamax, but Ortho-McNeil will lose their patent on the drug in 2008, which will make it available generically and thusly much more affordable…if you can wait that long.

Articles like this bother me.

His excessive sleepiness isn’t due to a lack of Provigil in his blood. Treating the symptom and not the disease may be ok for a physician earning 75 dollars per office call, but it only serves to make the subject drug dependent. That’s exactly what it is; and it is not necessarily related to the abuse potential of the drug. Tylenol has zero abuse potential, but that doesn’t preclude someone becoming dependent on it due to the abnormal amount of headaches they experience. If a person takes Tylenol everyday to mitigate the effects of a chronic headache, they are dependent on the drug. The headaches are due to a behavioral or environmental factor, not the lack of Tylenol in the blood.

What Mr. Kim needs is behavioral modification, not a reliance on an exogenous chemical to rectify his self imposed work overload.

The above comments were helpful. Thanks, y’all!

I went to see my doctor some time ago. I mentioned Provigil before the visit, so he was prepared to discuss it.

He wrote out a prescription for me, but he said that before filling it I should try to sleep earlier and decrease a certain medication. If these two steps don’t help, perhaps then I could try Provigil. I did both, and it did make a difference. But then the old problems were coming back.

I began taking Provigil, but what I noticed is that while it kept me awake and alert during the day and whereas I had no problem falling asleep, it was extremely difficult to get up in the morning. So, I stopped it. For some odd reason, I don’t feel as tired or fatigued any more.

Nevertheless, I have the pills, but I’m not using them. I think I’m going to straighten up my sleep schedule, exercise, and control by blood sugar levels better.

Provigil didn’t really do what I thought it would make me do. I envisioned being really active, ready to go and move about and get things done. It just kept me awake. I honestly saw little difference between being on a caffeine pill and being on Provigil. So rather than dose up on more meds, I’ll try to pull my bootstraps, so to speak, and straighten out my life. Who knows - most likely this way I’ll be able to get off most of the other meds I’m taking.

WRS

I’m glad THAT got cleared up! I’m glad my body produces enough mold-based antibiotics that I don’t have to take that nasty Penicillin supplement… :rolleyes:

My doctor prescribed Provigil for me because I have delayed sleep phase insomnia and he wanted me to reset my circadian rhythms with this drug. It did not work. I was able to take it and go back to sleep for 4-5 more hours, even nap. He told me to try taking two, but then I couldn’t sleep at all at night. I have no idea why it would work for fighter pilots and not for me, but hey, that’s what happened.

Good luck dealing with your insomnia and depression. As a fellow sufferer, I wish you well.