"Related" characters from different sit-coms

The Game Room
#1

Consider the statement:

“John Goodman is Debra Messing’s half-brother.”

This can only be true because Debbie Reynolds played Dan Conner’s mother in “Roseanne,” and she also played Grace Adler’s mother in “Will & Grace,” though she had a different husband.

So . . . each player will name a cross-sitcom relationship, and the next player will explain it, and name a new one.

Ok.

Valerie Mahaffey is John Mahoney’s daughter-in-law.

#2

On “The Powers That Be,” VM was married to David Hyde Pierce, who played JM’s son on “Frasier”
Jean Smart is Jennifer Aniston’s mother.

#3

Jean Smart plays Christina Applegate’s mother on “Samantha Who.” Applegate played Jennifer Anniston’s sister on “Friends.”

Jill Whelan is Valerie Bertinelli’s step-sister.