Krish-I know what a homologous gene is. I personally wouldn’t use the word to describe the X and Y.
I took me less than a minute to find this on PubMed; in fact, it was the first abstract listed when I search “Y chromosome gene”
Lau YF, Zhang J; Expression analysis of thirty one Y chromosome genes in human prostate cancer.; Mol Carcinog 2000 Apr;27(4):308-21.
From the abstract:
Rapid advances in positional cloning studies have identified most of the genes on the human Y chromosome…Results from this expression analysis of 31 of the 33 genes, isolated so far from the Y chromosome…The last group includes X-Y homologous (e.g., ZFY, PRKY, DFFRY, TB4Y, EIF1AY, and UTY) and Y-specific genes (e.g., SRY, TSPY, PRY, and XKRY).
Here’s the link: http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10747295&dopt=Abstract
Six genes out of 33 on the Y (so far). That’s not a lot. Maybe you could let me know how many genes are located on the X.
This is what I found:
D. L. Nelson, E.E. Eichler, B.A. Firulli, Y. Gu, J. Wu, E. Brundage, A.C. Chinault, M.Graves, A. Arenson, R.
Smith, E.J. Roth, H.Y. Zoghbi, Y. Shen, M.A. Wentland, D.M. Muzny. J. Lu, K Timms, M. Metzger, and R.A.Gibbs;
Mapping and Sequencing of the Human X Chromosome;
Department of Molecular and Human Genetics and Human Genome Center, Baylor College of Medicine, Houston, Texas
The human X chromosome is significant from both medical and evolutionary perspectives. It is the location of several hundred genes involved in human genetic disease, and has maintained synteny among mammals; both of these aspects are due to its role in sex determination and the haploid nature of the chromosome in males. We have addressed the mapping of this chromosome through a number of efforts, ranging from long-range YAC-based mapping to genomic sequence determination.
Here’s that link: http://www.ornl.gov/TechResources/Human_Genome/publicat/96santa/mapping/nelson.html
Six genes out of x on the X. It’s not my area, but it seems to me that the Y has about 30-40 genes and the X has “several hundred”.