Second many of the above and add, The Notebook by Nicholas Sparks.
“The Milagro Beanfield War”. I laughed so hard, tears were streaming down my face. Same for the second reading.
My Brother Sam is Dead by Patty M. Blome.
Read it for the first time in 4th grade. The only book I have ever read that made me shed a tear.
Where the Red Fern Grows
The Color Purple
Rocky 2
Old Yeller
The Wizard of Oz
Dragonfly in Amber, when Jamie is sending Claire back through the stones.
I love that series, and I’ve read it several times. The first time, though, I actually put the book down and screamed into my pillow.
“I felt my heart breaking. It made a small sound, like the snap of a flower stem.”
Then I read Voyager, and I cried again, for an entirely better and happy reason.
I love Diana Gabaldon. What a fabulous writer she is.
The last two pages of RotK, at the Grey Havens. Doesn’t mater how many times I read the books, every time I get to the end I cry.
Hell, I tried explaining why it made me cry and I got all sniffy. My friends thnk I’m a sad geek now.
And the last chapter of Winnie the Pooh, because I remember my dad reading it to me and explaining that CR was growing up and going to school, which is why there’s no more Pooh stories. Sniffle.
One of John Steinbeck’s books that I read ages ago made me howl. Cannery Row/Lane, maybe.
Meh, now I’m all depressed.
Oh, Progo …
Cyrano de Bergerac. I know it’s a play, but I’ve read it many more times than I’ve seen it.
The biggies:
Charlotte’s Web
The Last Battle
Bridge to Terabithia
Spoiler for Bridge to Terabithia:
My fifth grade teacher read “Bridge” to the class, but I missed the last day. I came back and asked my best friend Matt what had happened. He told me that she died, and I couldn’t believe it. I said, “No she didn’t.” And he just kept telling me she had died. I refused to believe it. I was still refusing years later when I read the book. I kept telling myself that he was just making fun of me.
Enemy Mine
One of the books by Martha Grimes, I think it’s Help the Poor Struggler. It makes my heart hurt.
And the one that I can’t even read an excerpt from without bawling, James Joyce’s “The Dead.”
sob
Julie
Is anyone else unable to reread books that make you cry? I can’t touch Bridge to Terabithia, for example. I just can’t. I try to avoid reading sad books entirely because they are capable of putting me into a depression for days. Am I alone in this?
Julie
Dorothy Dunnett’s Pawn in Frankincense. The chess game gets me every time 
I just finished The Lovely BonesCried all the way through it. Also In the children’s books * The Velveteen Rabbit, The Caretakers of Wonder*
“So in America when the sun goes down and I sit on the old broken-down river pier watching the long, long skies over New Jersey and sense all that raw land that rolls in one unbelievable huge bulge over to the West Coast, and all that road going, all the people dreaming in the immensity of it, and in Iowa I know by now the children must be crying in the land where they let the children cry, and tonight the stars’ll be out, and don’t you know that God is Pooh Bear? the evening star must be drooping and shedding her sparkler dims on the prairie, which is just before the coming of complete night that blesses the earth, darkens all rivers, cups the peaks and folds the final shore in, and nobody, nobody knows what’s going to happen to anybody besides the forlorn rags of growing old, I think of Dean Moriarty, I even think of Old Dean Moriarty the father we never found, I think of Dean Moriarty.”
And now my eyes are full of tears. This is the last paragraph (actually a long run on sentence) from “On The Road” by Jack Kerouac. One of my all time favorite books, and most of it really happened. The narrator (Sal Paradise) is based on Kerouac himself, and the Dean Moriarty character on his close friend Neal Cassady. The poet Allen Ginsberg also appears as “Carlo Marx,” as do several other Beat Generation writers under assumed names.
Many short stories by O. Henry.
Two especially good ones:
A Retrieved Reformation, featuring the gone-straight safe-cracker Jimmy Valentine:
http://members.tripod.com/~drugnicity/henry.html
And An Unfinished Story, a heart-rending account of the grinding poverty endured by a turn-of-the-century New York shopgirl:
Yep! Me too – stupid, stupid rabbits
To this day, when I have to do something important, but I’m afraid that I might not be brave or assertive enough, I’ll think to myself, don’t go tharn! I read that book when I was in the sixth grade, and it affects me still.
Stupid, stupid, stupid rabbits.
Bizarrely, both books have to do with dogs, and I am not a dog person, as my two cats can tell you. BUT…
Spoilers a-comin’-
House of Leaves, when the skanky ho Johnny has hooked up with throws the Peke pup out the window…well, it’s just too much.
But even worse, Riddley Walker, when Riddley’s traveling companion, the black dog, noses his hand for the first time, I cry like a baby every single time.
I’m a geek gal, and no mistake.
The first of Naguib Mahfouz’ Cairo Trilogy - “Palace Walk,” partially due to Mr. Mahfouz’ outstanding ability to give real depth to his characters, and of course, the ending.
Another vote for The Little Match Girl. Heres how pathetic I am - in Tivoli, the amusement park in Copenhagen (HCA was Danish), they have a ride where you go past audioanimatronic scenes from Andersen’s stories. I choked up every time I rode past the Little Match Girl scene.
I also cried during The Poisonwood Bible, by Barbara Kingsolver, IIRC.
I can never finish Heinlein’s The Man Who Traveled in Elephants without tearing up. Spider Robinson says the same thing, and claims that Heinlein told him that was his specific intent in writing the story.
TubaDiva, I also tear up at the chapter in Wind in the Willows where Rat and Mole return to Mole End at Christmastime…