All My Children (which was, IIRC, the first soap to have an openly gay character), is introducing a story line about at transgendered character – link.
They’re going to wait and see what audience reaction is before deciding whether to follow through with it or not … whaddya think, hit or miss?
There was already a transgendered character on a short-run soap the City back in the mid-90s. The character was played by a female-since-birth actress. (who didn’t in any way look like she could ever have been a man.) She was also written out of the show almost immediately after the big reveal took place.
“One Life to Live” also briefly introduced a transgendered character in the mid-90s, this time actually played by a M2F transgendered person, a bartender at “RJ’s” nightclub. But likewise, the character was kept on the back-burner and written out very quickly.
Um, since Mrs Doubtfire was a) not transgendered and b) a character from a film, I would say the answer is “no.” Actually I’d say more but (checks forum) never mind.
David Duchovny played a transgendered FBI agent on Twin Peaks. At least, that’s how I remember the role. It’s possible that the agent was a transvestite. My memory of Twin Peaks is a bit dim.