SSRIs make my friend toss her cookies.

All of them, doesn’t matter which one, and on a daily basis. So she stops taking them as daily puking isn’t really good for you, gets depressed and self-destructive again, and starts taking them again, and starts puking again.

Her doc is fully aware and is essentially telling her “them’s the breaks; you’ll get over the side effects eventually”, but after two months straight daily vomiting she gives in.

There’s gotta be a better plan, right?

Two months daily puking and the doc tells her tough?

Get a new doctor. There’s other non-SSRI antidepressants out there.

If the depression responds to SSRIs and little else, perhaps she could try something like Stemetil/Compazine/Prochlorperazine for the nausea and vomiting. I had to take Salazopyrin at about age 12 for a time to put ulcerative colitis into remission, and had a response to it that was similar to what your friend is experiencing. Since it seemed imperative to treat the UC, I took Prochlorperazine in long acting spansule form with the Salazopyrin, and the side effects were diminished significantly, though I would still get motion sick in cars and whatnot. Anyway, it’s worth a try.

Is she on extended-release forms of the meds? (those come in capsules rather than tablets) Is she being started at a low dose which is gradually increased?

Extended-release forms and lower doses tend to play nicer with one’s system than the opposite. One would presume, though, that a competent physician would already know this and would have taken this into account.