In the Voyager episodes involving the Equinox, we find the Equinox is harvesting living organisms to fuel their amped up warp drive. Voyager is startled from a moral point of view, but I don’t really recall them being surprised from a tech POV. That’s some forward thinking there since as an audience member there was definitely a disconnect for me.
Same in Star Trek Discovery and their spore drive. Again I don’t really remember how shocked the cast is, but as an audience member it’s kinda best described as ‘unsettling’? Ooogie??
A little less so in Enterprise where the doc uses all kinds of organic remedies.
But…Star Trek gets it right again:
Thats a link about bacteria-filled water being used as a superfluid.