What would happen to the human body if one took synthetic opioid carfentanil , I would like to know the scientific process out of curiosity
Well, if you want to know how to produce illegal drugs, I’m thinking that you’ve come to the wrong place. 
WHAT?? no just the effect on the human body lmao
Death could happen.
Google says these are the effects of accidental exposure to humans:
… Symptoms of human exposure and overdose
Due to its rapid and powerful effect on the central nervous system, symptoms of exposure can appear within minutes and may include:
- Respiratory depression or arrest (slowed or stopped breathing)
- Extreme drowsiness or sedation
- Disorientation or confusion
- Pinpoint pupils
- Cold, clammy skin…
Tiny, tiny amounts can be lethal to humans. It is a large animal sedative, like elephants, rhinos and moose.
Synthesized drugs are usually more potent than their natural counterparts, and carfentanil is no exception. It is 100 times stronger than fentanyl and 10,000 times more potent than morphine. That’s ridiculous, and the effects of something that powerful are devastating. Think OD deaths are bad now? Imagine a carfentanil epidemic.
As you’ve noted it’s a synthetic opioid, just an incredibly potent one. It’s about 10k times more potent than morphine and dosages are in micrograms rather than milligrams so miscalculations in dosage may much more easily result in respiratory depression and death. It’s also very tightly bound to the opioid receptors, so it takes massive doses of naloxone to reverse an overdose. Beyond that its pharmacology is like that of agonist opioids in general.
thanks
true .<.
thanks for the info
;-; Yeah… was just curious
Second-hand report here, so no cite: but a friend told me that when loading darts with the carfentanil, the strict protocol was that nobody, nobody ever worked alone to do that. A second person always stood by with the massive doses of Naloxone that Qadgop mentioned.
That’s how potent the stuff is.
If micrograms can kill a human, then milligrams could kill an elephant. So it’s a decent bet the serum being loaded into animal tranquilizer darts isn’t 100% active ingredient. But for damn sure the entire charge, being sized to knock out an elephant quickly, albeit temporarily, would knock out a human both quickly and permanently.
Decent bet if a human did receive an appropriate therapeutic dose of carfentanyl it’d work about like fentanyl does with similar objective and subjective effects.
The manufacture of reliable dosing systems for stuff that potent is definitely not trivial. But many many patients all over the world consume fentanyl safely day in and day out. And yes, a bunch of idiots abuse it too. But it can be dosed safely when manufactured properly and used judiciously for its intended purposes.
Pretty much this. However the FDA considers (and rightly so) that there is no appropriate therapeutic use for humans for carfentanil due largely to difficulties in being able to reliably measure out the incredibly tiny dose to be delivered for a therapeutic effect.
Makes sense; thanks.
My late wife was on continuous fentanyl for 7 years. Stopped the pain and mostly left her thinking and ambition intact. I for one am damned glad the stuff existed when we needed it. She’d say the same were she here to do so.
But trying to dose something 100x as potent as that? Yowza. You’d be talking nanograms per hour.
We’ve seen that casual exposure to fentanyl (i.e. briefly touching it or entering a user’s residence) has led to fainting and other deleterious symptoms without a physical cause in police and other first responders (so-called “fentanyl hysteria”). It appears doubtful that similar exposure to even highly potent fentanyl analogs poses significant dangers.
The linked statement mentions a veterinarian who was splashed in the eyes and mouth by a solution containing carfentanil and became drowsy despite washing immediately (he responded well to naloxone). There was an incident in Russia where numerous deaths resulted when aerosolized (weaponized) carfentanil was used against terrorists. But that’s much different from, say, briefly handling a packet of heroin cut with carfentanil. Big danger to the addict, very little to the first responder.
One of the things I recall reading about fentanyl - perhaps also applicable to car..
The grains of the product from its manufacture process are fairly strong and require care and effort to grind small enough to get an appropriate measured dose. Obviously those diluting it for street distribution rarely concern themselves with quality control, so there is a strong possibility of irregular mixes where some quantities may contain larger crystals and so be significantly higher doses than expected.
I got curious. Not elephants, but moose:
3 or 4 mg sounds like a lot (in the context of this discussion) but then darting is, I presume, intramuscular or subcutaneous delivery, rather than intravenous dosing (unless you get unlucky). Paging @Qadgop_the_Mercotan - does this sound like a reasonable explanation of the seemingly large dose? Given the strong binding to receptors, would that ultimately even matter? (That is to say, would the full dose eventually leach into the system and find its way to receptors faster than it could clear, absent the use of naloxone?)
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Sure, since it’s essentially given IM that way. Giving that IV push to a moose or elephant could well result in death. Of course I’ve not studied the specifics of opioid receptor sensitivity in species other than human so take that with a grain of salt, but not with a microgram of carfentanil.
Could you explain this a bit? I’m not really understanding why measuring a tiny dose is difficult. If you need to administer 20 ug from a high dose solution, it seems to me you just need to dilute it. Even homeopaths know how to do that. Do four 10x dilutions and you’ve reduced it to 1/10,000 of the original concentration. What am I missing that makes this a difficult process?