Dr. Smith - Lost in Space
The Borg from Star Trek: The Next Generation
Bumble - Rudolph The Red-Nosed Reindeer
Burgermeister Meisterburger - Santa Claus is Comin’ to Town
Winter Warlock - Santa Claus is Comin’ to Town
Snow Miser - The Year Without a Santa Claus
Heat Miser - The Year Without a Santa Claus
Professor Hinkle - Frosty The Snowman
Ben Haramed - The Little Drummer Boy
His identical twin brother hit it big over at Pixar. 
Oh, come on. We all knew it really was:
Gilligian – Gilligan’s Island.
Foiled every one of their plans.
I nominate, for the Role of Most Bumbling Villain In An Animated TV Show, Doctor Drakken, of Kim Possible.
Lord Ishido, from the Shogun miniseries
J.R. Ewing, from Dallas
Wo Fat, from Hawaii 5-0
The Smoking Man, from X-Files
evil Angelus, from Buffy
Mayor Wilkins, Buffy
Major Frank Burns and Colonel Flagg from MAS*H
C. Montgomery Burns, the Simpsons
Mojo Jojo, the Powerpuff Girls
Plankton, from Spongebob
Dick Dastardly
Snidely Whiplash
Joker and Catwoman, Batman
Lionel Luthor, Smallville
Doctor Loveless, Wild Wild West
Frank Nitti, the Untouchables
Dr. Zachary Smith, Lost in Space
Alexis from Dynasty
Callisto, from Xena
Major Hochstaetder, Hogan’s Heroes
The Island - Lost
LOL - My favorite line…“You got me monologuing!”
Almost every one.