I’m in Hanover, NH, at Dartmouth College. I hear it’s known for a few things.
Orlando, FL, where I used to live, has the record for most lighting strikes per year, IIRC.
Boca Raton, FL, where I currently lives, probably has the most old people from out of state. 
Providence - the first US state capitol to elect an openly gay mayor.
The Providence Arcade was the first shopping mall.
We also have the highest number of donut/coffee shops per capita according to wikipedia.
in 2005, Baltimore had the highest homicide rate for American cites with populations over 250,000. And even when it doesn’t win this category, it’s usually in the top three or four. This year, we’re looking like topping the 300-homicide mark for the first time in a while, which will probably put Baltimore at or near the top again.
On a more upbeat note, the city is famous for a bunch of things, probably too many to list here. But that’s probably true of just about any city that’s been around as long as Baltimore has.
Famous names associated with Baltimore include H.L. Mencken, Babe Ruth, Billie Holliday, Frederick Douglass, Cal Ripken, Eubie Blake, Edgar Allen Poe, Thurgood Marshall, and a bunch of others.
Apparently Baltimore was the first city in America to adopt 311 as a non-emergency police number.
John Wilkes Booth is buried about 10 blocks from where i live.
Johns Hopkins University was founded as the first modern research university in the United States in 1876.
Don’t let those folks in Wisconsin tell you otherwise; Ithaca, NY is the true birthplace of the ice cream sundae.
There’s also some university here.
Vancouver, British Columbia
Widely considered to have the best/most cannabis in the world.
Incidentally(?), often considered to be the most liveable city in the world (or at least in the running).
The first non-stop trans-Pacific flight ended here.
Also, those sex rings you may have heard about.
Durham, NC
The last major Confederate army surrendered to the Union in the American Civil War about half a mile from my house.
Phoenix.
I suspect (although I don’t know for sure) that we have more days over 110°F than any other major metropolitan area in the US (maybe the world). 32 this year (a new record, woohoo!).
I should also add something about the neighborhood I live in now, Minami Senju.
It’s evil.
No, really. According to the old geomancy beliefs (maybe the same as feng shui nowadays), evil comes from the northeast, and Minami Senju is directly northeast from the Imperial Palace. Pretty much everything that nobody wanted in their backyard for the last four centuries has been put here. Right between the two train stations is a temple that now sits on the old Kotsukahara execution grounds, where (according to Wiki) over 200,000 people were executed in the 250+ years it was active.
There is also a cemetery for the prostitutes who worked in the ‘floating city’ of Yoshiwara during the centuries that that was active. The main streets through the neighborhood are “The Bridge of Tears Road” and “Bone Street”, where the heads of the executed were put on display.
Man, I love this place.
The valley in which I live was the place where the 49ers first found a reliable source of water coming out of Death Valley after their ordeal there.
The trip across the valley is probably 15-20 miles on their route and it took them 7 days to make it.
The spot is called Indian Wells. The wells are still there and they are the site of a microbrewery.
John Dillinger was caught here, at the Hotel Congress, I believe, downtown.
Downey, CA’s claims to fame:
The oldest McDonalds still operating, and the birthplace of Taco Bell.
The birthplace of Weird Al Yankovic, and the place that gave you both The Carpenters and James Hetfield of Metallica.
The plant where the majority of the parts for the Space Shuttle were built, as well as much of the Apollo missions, was here, and the nearby intersection of Lakewood boulevard and Firestone Boulevard was at one time the busiest intersection in the world.
Marilyn Monroe and Clark Gable made a pretty bad film right here together. Those fucking horses still wander around here. They decimated my neighbor’s garden the other day. I don’t really like her, so I got a kick out of it.
Fairfax, Virginia has George Washington’s will, although there is a political cat fight of nearly seventy years duration over whether it should be displayed at Mount Vernon, his home, or at the Courthouse, where it was filed. (Everyone else’s will was either archived, or burned by the damn Yankees when they occupied the courthouse, during the great unpleasantness of 1863.)
It is also the location of the first Confederate casualty during that same war. Peyton Anderson was shot while on picket duty down in front of the Best Western Motel. (The motel was built later. It was pretty much woods, and a cow path, back when Peyton got shot.)
That’s as close as we get to famous, I think. All the famous stuff happened in Alexandria, down the road.
Tris
I give you Ipswich ware, and the Ipswichian interglacial era. I know, calm down, calm down.
Also Britain’s youngest Grade 1 listed building. Which is looking rather spritely, given that it’s approaching 40.
As for my actual home town just outside, we’ve got this, although it’s actually on the other side of the river.
Lots of stuff.
-The Island of Montreal is the world’s most populous island on fresh water. It is more populous than Manhattan.
-Montreal used to be Canada’s largest city.
-Also used to be its capital.
-Was the birthplace of Canadian industry.
-We may or may not, depending on your definition, be the second largest francophone city in the world after Paris.
-We have the highest proportion of post-secondary students of any large city in North America.
-World’s tallest inclined tower.
-Largest botanical gardens in the Americas
-Held what is widely regarded as the most successful World’s Fair ever.
-Largest church in Canada (St. Joseph’s Oratory).
-Hôtel-Dieu was one of North America’s first hospitals (1659); in 1868, it saw the world’s first removal of a kidney.
-Sun Life Building used to be largest building in the British Empire.
-Tour de la Bourse used to be the tallest concrete building in the world.
-World’s first metro to run entirely on tires.
-Largest gay village in North America.
-Montreal Convention plugged on most airline tickets.
-Montreal Protocol on reduction of ozone depleting substances.
-Declaration of Montreal on LGBT human rights.
-Canada’s only museum of contemporary art.
-Birthplace of the Cirque du Soleil.
-World’s longest underground city.
-Pre-eminent fireworks competition and comedy festival.
Music!
The Grand Ol’ Opry
Insurance companies
Melbourne, Australia - spurious claim to fame that it is the only city in the world to have hosted 5 of The Beatles at one time (only one night - the regular 4 as well as the replacement drummer who took over while Ringo had a tonsilectomy).
I don’t live close enough to Denver to brag on all of the mile-high city’s fame and infamy. Out here in the northeast corner of Colorful Colorado about all we have is Julesburg (a moderately famous but vice-ridden stagecoach stop on the Overland Trail) and Sand Creek, site of the massacre of more than 160 Arapaho and Cheyenne Indians, mostly women and children – not Colorado’s proudest moment, by a long shot. This area is probably best known as the setting for James Michener’s “Centennial,” which contains a fictionalized but still harrowing account of the massacre.