The first potato grown in Europe was planted in my town.
Henry III held his parliament on a field near our house.
Jersey City, NJ, is the (real) home of the Statue of Liberty as well as the world’s biggest clock (supposedly). It’s also home of the Black Tom Explosion of 1916, when Germans set fire to a railway yard full of supplies for the allies during WWI, including lots of ammunition. Also, our mayor was recently arrested outside a bar down the shore for obstruction of justice. But he’s still better than a past mayor.
The closest town to me is Alma Colorado. Highest town in the US. Well, Winter Park claims to be the highest, but the only reason is because they annexed the ski area. The only structures above Alma’s elevation are ski lifts and out houses. I think that’s cheating.
[ul]
[li]is the smallest self-governing county in the United States.[/li][li]the most educated city (percentage of residents with graduate degrees) in 2006 by CNN Money[/li][li]is the location of Arlington National Cemetery and the Pentagon[/li][li]used to be part of DC, but was retroceded to Virginia in 1846-7[/li][li]home of Robert E. Lee[/li][li]A person standing on Memorial Bridge in Arlington is exactly as far from the Cumberland Gap, Virginia’s western extreme point, as they are from downtown Boston, Massachusetts - 394 miles[/li][/ul]
Corpus Christi, TX is supposedly the 2nd best place for wind surfing and kite boarding.
Palatine, Illinois - home of the Brown’s Chicken Murders!
Wrap THAT up in your town newsletter and smoke it!
Birthplace of the nation. Other than that, not much. 
0-17
Grants- “Uranium Capital of the World”
Milan- “Carrot Capital of the World”
(Although I was 0-18, these things were true in the 70s and early 80s)
18-23
Socorro- EMRTC (Energetic Materials Research and Testing Center)- NRAO (National Radio Astronomy Observatory)- VLA (Very Large Array)- MRO (Magdalena Ridge Observatory)Langmuir Laboratory for Atmospheric Research
24-25
Santa Fe- San Miguel Chapel is the oldest church structure in the US. I believe it’s the church that has a spiral staircase that doesn’t use any nails or a center post. It’s the highest state capital (7,000 ft), and is known as “The City Different”.
As recently mentioned in this thread, the town where I live has its own strain of Ebola. 
Nothing particularly impressive.
World’s only inland pier ( )
Orwell lived as a tramp here and wrote a book about life here and in the surrounding towns.
The village next to mine was the site of one of the UK’s worst coal mining disasters, with around 350 men and boys losing their lives in an explosion.
A legend, surrounding a stately home in my village, is written into Waverly, by Sir Walter Scott. The same estate also had one of the world’s greatest private libraries.
Wigan was also staunchly Royalist in the civil war, hence the town’s motto “Ancient and Loyal”, as well as the nickname for the people of the town - “pie eaters”, as Royalist towns were made to eat humble pie after defeat of the Roalist forces.
Wigan was, the last place where Cumbric (aka North Welsh) died out. The language was spoken all throughout the north west of England, all the way up to Strathclyde in Scotland.
Luton is the U.K.'s #1 crap town.
While my location may say Chicago, I actually live in Oak Park.
We have a number of Frank Lloyd Wright designed buildings including Unity Temple and Wright’s home and studio.
It’s also the birthplace of Earnest Hemmingway and Bob Newhart among others and according the wikipedia link at the top of this post a bunch of other famous people decided to come traipsing through here at one time or another.
In 1947, a couple of “illegal aliens” lost control of their vehicle and crashed a few miles from here.
Some said it was a weather balloon.
Toronto:
Home of the world’s [sub]second[/sub]-tallest free-standiong structure. (Curse you, Burj Dubai!)
Home of North America’s only (allegedly) shoe museum.
Home of the busiest highway in North America, the evil death highway of doom known as the 401, which is up to 22 lanes wide.
Where I now live is the Home of the First Ironworks in America, not to be confused with the first ironworks in America down in Quincy, MA, or the first ironworks in America down in New Jersey, or anything the Spaniards may have set up in St. Augustine or Mexico City or anyplace.
It is pretty cool – they’ve excavated the site and found the original water wheel and wonkin’ big foundry hammer, and they’ve reconstructed the whole thing (and it actually works), but it’s all undergoing repair and renovation and won’t open again until next year.
The Farrelly brothers, of There’s Something about Mary, etc. fame are from here. They almost never film on location, even though they appear to. Except for some of the scenes from Dumb and Dumber which involved the dog shaped car? (I haven’t seen the movie.)
Wapakoneta, OH is the birthplace of Neil Armstrong. According to the locals who remember him- he went to the moon to escape Wapak, and never returned to Wapak thereafter.
Natchez, MS- The oldest city on the Mississippi River. Also probably hold a record for number of Antebellum houses, as Natchez was not burned during the Civil War.
I used to live in Huber Heights , OH, “America’s Largest Community of Brick Homes.”
Half the message board posters on the internet claim to have committed murder here. Curiously enough, they all use the same syntax…
“I shot a man in Reno just to watch him die.”