Nuh-uh. Rosa Klebb may have been a bisexual sadist, but of good white stock.
Actually, to the best of my recollection, only a few Fleming villains were mixed race, and for even fewer was it significant:
Casino Royale: Le Chiffle might have been Jewish or part Jewish.
Live and Let Die: Mr. Big was black. I guess there might have been a passage hinting he was part-white, but memory fails me.
Moonraker: Hugo Drax was minor German nobility, which I figure is as white as it gets.
Diamonds Are Forever: Jack Spang (Rufus B. Saye); Seraffimo Spang, Wint, Kidd… all white, unless you want to claim Fleming made a distinction between white and Italian, which I understand would not have been unusual 50+ years ago.
From Russia, With Love: Rosa Klebb (white), Red Grant (half Irish, half German), Kronsteen (Jewish, I assume), General G. (white).
Doctor No: Dr. Julius No, the first mixed-race villain (white/Chinese) for which the racial mix was significant, given the character’s history and motivation. His various goons were “Chigroes”, Chinese/Negro, who considered themselves above the Negros (though below the Chinese). Bond’s ill-fated buddy Quarrel was black with some white in him.
Goldfinger: Auric Goldfinger. Might’ve been part-Jewish, Bond speculates, but definitely Baltic, he later figures. Goldfinger’s goons, notably Oddjob, are Korean.
For Your Eyes Only (Short story collection):
- From a View to a Kill: Russian spy group. No racial aspect explored. I assume white.
- For Your Eyes Only: Von Hammerstein (German), Gonzales and thugs (Hispanic).
- Quantum of Solace: None.
- Risico: Kristatos and thugs (Greek).
- The Hildebrand Rarity: Milton Krest (white, American, lout, creep).
Thunderball: Ernst Stavro Blofeld (Polish.Greek). Emilio Largo (Italian, I assume). Various SPECTRE goons of various ethnic backgrounds.
The Spy Who Loved Me: Horror, Sluggsy (generic American thugs).
On Her Majesty’s Secret Service: Blofeld, Irma Bunt (German, I guess, though some of her history was briefly described). More SPECTRE goons of various ethnicities.
You Only Live Twice: Blofeld and Bunt, and various Japanese goons.
The Man With the Golden Gun: Pistols Scaramanga (Spanish Catalan, though the expositional Secret Service biography compiled on him pointlessly and quaintly suggests he might be a latent homosexual. No evidence of this appears in the character’s actions). Plus assorted hoods of Italian, Russian descent.
Octopussy and the Living Daylights. Short stories:
- Octopussy: Major Dexter Smythe. White guy. An older version of Bond, I’d guess.
- The Living Daylights: “Trigger”. Blonde woman. Attractive to Bond.
- The Property of a Lady: Unidentified resident director of KGB in London (white, I assume), Maria Freudenstein (German, as I recall).
There are a few dated sentiments expressed here and there, but it’s incorrect to say race (let alone mixed-race) was a significant factor in most, let alone all, Fleming villains. It’s only very significant for Doctor No, arguably somewhat for Mr. Big, and for the rest not at all.