The "de" prefix and hyphen use

I’m curious about rules concerning hyphen use and the “de” prefix.

Here’s an example. In some industries we superheat steam and then desuperheat it where it’s ultimately used. There’s a listing for superheat in dictionary.com but no entry for desuperheat.

So is it desuperheat or de-superheat?

Is there a general rule to follow?

From the Chicago Manual of Style, 13th edition (not the latest)

They list a few exceptions, none of which would apply to your case. However, they go on to say:

So, generally, you don’t need to use a hyphen, but if you think it would help avoid confusion don’t hesitate to use one.

I have no cites, but what I’ve seen most often in print is that the hyphen seems to be used whenever the prefixed form wouldn’t be a reasonably familiar word. So you can debone fish, because that’s a word most people will have seen in print before. If you’re making up a new word, though, hyphenate it so that it’s more obvious to your reader, especially if it could be confused with another word.

Cool.