I-5 between the Altamont Pass and the Grapevine. Those windmills in Livermore are the last interesting thing you’ll see (southbound) for the next couple hundred miles. Unless you’re really interested in lettuce fields.
It’s true that taking CA-1 adds a couple hours to the trip, but it’s approximately 5 trillion times more scenic.
We could, other than that I-70 from Denver over to most of Colorado’s western Slope is breathtaking.
I’d vote for I-80 from Omaha to, well, Reno. (Other than the Summit east of Laramie.) And I-10 through West Texas is right up there.
I won’t vote for any of those 20 mile stretches back east… if the boredom doesn’t last for at least a full day or two’s drive, it’s too puny to count.
I can definitely support that highlight! If you’ll indulge me a moment to brag, my father was the structural engineer responsible for making the memorial section of the Berlin Wall in front of the Memorial and Library (considered “the most important monument to be constructed on American soil since the Vietnam War Memorial”) stand up. 
Route 31 in Oman from Muscat to Salalah… about 1000km with only two tiny settlements of any significance.
Route 80 across Wyoming. Not even many towns to break the monotony.
I-15 going south in Utah gets pretty dull between Provo and St. George.
I’d say I-16 from Macon to Savannah. All it is trees and more trees. There is hardly any traffic most of the time too.
I-74 between Indy and Cincinnati is pretty boring as well.
Fiz-iffed!
I live in BFE Nevada, and this stretch of road didn’t interest me. If it weren’t for rain and hail, I’d have fallen asleep and crashed…into nothing!
I’ve driven through every state in this country except Kentucky and Hawaii(just for fun when gas was cheap) and the worst, I-80 coming from Nevada toward salt lake, its not even the pretty kind of boring, drab, flat, straight, ugly and boring.
At least on 40 you know you are going to hit Amarillo, get a good steak(a really really big one) and find a titty bar with real women (not glorified skeletons).
10 to 20 El Paso towards Dallas is pretty crappy too, except they supposedly raised the speed limit to 80, which means you can now do 115 instead of 110 which lowers the boredom a bit I guess.
I-70 & I-80 across any of the midwestern states (how many friggin’ cornfields can there possibly be)
I-10 across any of the southern states
I-55 from Chicago to St Louis
If you’re looking for a short drive that will place you into a quick coma - 288 between Houston & Freeport
If timing allows, I take my life in my own hands and travel the 2 lanes.
And I-74 between Bloomington and Indy.
It doesn’t get any better between Bloomington and the Quad Cities
I-57 between Champaign and I-80. Absolutely nothing to see, but it’s only about an hour and a half. However I’ve driven it roughly a bajillion times so it grates.
Well, your link refers to Hwy 50, not I-80. However, the stretch of I-80 that I found stultifyingly boring was further east, from the Utah border to the mountains around Salt Lake City, which passes through the Bonneville Salt Flats.
And then there’s I-5 from Redding south to Sacramento. Not quite as dull as I-80, but there is a lot of truck traffic and nothing to look at, so it’s both boring and a chore.
Roddy
Dallas to El Paso along I-20 to I-10. Everything just dies and you start praying to see wind farms. 600 miles of nothing.
Lancaster, CA to Edwards Air Force base. The vast expanse of all the dry lake beds is quite monotonous. But the Joshua trees are nice to look at.
Whatever highway it was that Led Zeppelin wrote Kashmir about. (it wasn’t in Kashmir either, it was in Morroco.)
I’ll second or third I-40 between the Sandia Mountains in New Mexico and the Texas border, though at least when you get into Texas you can see grain elevators. (After 270 miles of nothing grain elevators start to seem interesting.)
I was going to say I-80 across Iowa, but I know exactly where you are talking about, and God yes, it is the most boring hour and a half ever.
Best things Omaha has going for it - you’re no longer driving across Iowa or Nebraska when you get there
I wouldn’t say it’s boring - a lot more varied scenery than some of the other candidates here - but I agree that it somehow bends reality so that it packs roughly twice the length of the state into its lanes. Friggin’ annoying drive and I’m always ready for Massachusetts by the time I reach Hartford.