When I read this article,, I was reminded of this thread started by Mississippienne when she was known as Nichol_storm.
As the article details, the “most probable theory” derived from recent research is that the Melungeons are descended from sixteenth-century Portuguese and Spanish settlers in what is now South Carolina. Other probable contributors to the Melungeon line are Muslim sailors sent ashore on Roanoke Island by Sir Francis Drake (the term Melungeon is said to derive from the Turkish melun can, which means “cursed soul” or “one abandoned by God”). Such tribes as the Cherokee, Creek, Catawba, and Pamunkey also figure in this fascinating and tragic story.