I have started a few threads on this in the past that did not go over too well. This is a slightly different angle. I am more interested in genetic changes as opposed to genetic expression. However I would like to draw a possible link between genetic expression and modification.
From what I understand every sensory experience involves neurotransmitters. All of these neurotransmitters have specific half-lives to them before they break down into amino acids and proteins. The half-lives of these transmitters vary greatly from milliseconds to hours in some cases. However, the residual amino acids and proteins linger much longer in the cerebral fluids that also include spinal fluids which feed the reproductive glands that manufacture the sperm. So this would mean that at any given time the condition of the fluids would reflect whatever was going on in that person’s life. Is there any chance these amino acids and proteins can affect the genetic makeup of individual sperm cells?
Nope.
In the sense of random mutation? Maybe as a long shot. Solar radiation from being exposed to the sun would do far more.
And in general, such random events, such as a random bit of UV, will affect a few cells out of millions. Nor will they affect cells uniformly, i.e. any random changes that do occur will differ from cell to cell, not all of them the same way at the same time.
Links to prior threads:
Neurotransmitters are not proteins.
Here’s the closest thing in actual science:
in this post I am curious about what happens after the transmitter breaks down. The amino acids primarily.
Never mind.
I asked AI what happens to the neurotransmitters when they breakdown and it said primarily amino acids
I eat amino acids all the time, but it’s not affecting my genes.
Speaking for myself, AI has a very long way to go before I trust its answers over a Doper’s.
Aceylcholine is a common neurotransmitter. It does not break down into amino acids. The choline gets taken up by some other type of cells and re-bound, I think.
Dopamine and norepinephrine are both composed of amines (I’m reasonably sure) but not amino acids, which are chemically a bit different.
Careful using AI for answers. It will not always give factually correct responses, until it has been trained to do so.
This is the chart that I posted and then removed (with the never mind)
(I removed it because it doesn’t cover every single neurotransmitter. Some of them do derive from proteins. But far from all of them.)
Thats why I came here
The reproductive organs are isolated within the blood brain barrier so would only have exposure to those within. that fluid. From what I understand the breakdown produces unique amino acids for each chemical it breaks down.
I’m not even sure what this is supposed to mean. Reproductive organs aren’t behind the blood-BRAIN barrier unless I’ve been doing something very wrong all this time.
As above, neurotransmitter breakdown doesn’t produce amino acids in general, so this line of thought is already starting from false premises.
Proteins are long chains made up from a toolkit of 20 different amino acids.
Well, for some, the brain seems to be co-located with the reproductive organs. 
(That’s not directed at anyone here, of course)
ETA: Wait! The better joke is: What about those who do their thinking with their other head?
That was very helpful, I gave it a quick read but plan to go back and try to digest more of it.
Yeah, I didn’t notice this part before it was quoted. That is just utterly, completely, profoundly factually incorrect. It is as accurate and sensical as saying that your car’s lugnuts are located inside the radiator.
The male reproductive system consists of internal structures such as the testes, epididymis, vas deferens, and prostate, as well as external structures like the scrotum and penis3. These structures are well-vascularized and produce important androgens3. The reproductive glands in a male are inside the blood-brain barrier