My answer: all or any of the above. Well, probably not the solar plexus - it’s a small target surrounded by muscle.
Better answer: I’m going to read his attack and block and strike appropriately. My karate training says to not get hit. My self-defense aspect focuses on multiple strikes to overwhelm the opponent long enough to stop their aggression and then get away.
Personally, I like a knee shot as they approach. They’re focused on punching you with a big haymaker, so use legs (they’re longer, they’ll connect first) and kick low where they aren’t looking. Followup as needed to get free.
Alternately, block the punch in a way that keeps you clear of the shot, and immediately strike. That’s likely to be a windshield-wiper block followed by palmstrike to face, strike to throat, knee to groin, then kick to knee. That’s my most practiced routine.
I do like the idea to redirect them into hard objects. They punch and hit wall instead of face, they aren’t going to want to punch again.
Nut shots can be completely disabling. We were self defense training and one guy didn’t pull his shot, hit another in the nuts. He was on the ground for a couple minutes.
However, it was pointed out that most boys quickly learn to protect the jewels, it becomes a reflex. You make a move and the leg comes over, the hips twist, the hands may drop. So the key to a successful nut shot is distraction.
Alternately, when I first started karate, I was sparring a guy and caught a shot to the kidney. I tell you now it was absolutely as disabling as any nut shot I’ve ever had. Took the air out of my lungs and left me immobilized. I crumpled to the floor without even a whimper and was stuck there for at least a minute. Never had that happen since, but that one time made an impression on me.
High school wrestling is a martial art. Grappling is combat.
Precision strikes are for suckers. Adrenaline makes precision a challenge, moving targets make them more difficult. That’s why I wouldn’t go for the solar plexus. The advantage of most of the targets listed in the OP is that they are effective targets that take little training to be useful.
A quick kick to the knee doesn’t take much finesse. Side kick, front kick, whatever. Catch them with their foot on the ground, you don’t even have to hit the knee, a hard thrust on the thigh can hyperextend their joint enough to make them gimpy. Ever bashed your shin? Your kick is low, you still hit the shin bone, that is still effective, even if only as a distraction for followup.
And I prefer palmstrikes over punches. An uppercut palmstrike towards the face can catch either the nose or the chin, and either way will do effective work. Followed by an elbow dropped on the throat for good measure.
