Hah.
The last I looked, God did not send an archangel down from Heaven with “one man, one vote” inscribed on tablets of stone.
The United States Senate is unrepresentatively apportioned for the very good reason that it was never intended to be representatively apportioned. It represents the equality of the states, at least in theory.
Under our system of law, 13 free and independent states surrendered to a new government which they together formed a portion of their sovereignty, so that the new national government would be supreme in the specific areas in which it had authority by that cession. The residual sovereignty which they did not cede to that national government inheres in them.
And in token of this, each state is entitled to equal representation in the Senate.
If it bothers you that this is so, you are free to seek two constitutional amendments, one deleting the final clause of Article V of the Constitution – since 1809, the only provision of the Constitution not subject to amendment – and one calling for apportioning of the Senate on the basis of population.
Alternatively, you might have those “respectably sized cit[ies]” seek independent statehood.
There is one additional thought to bring to mind in this: the will of the majority, under our system of government, does not always hold. Until and unless an overwhelming majority of the citizens believes that something is sufficiently wrong that the Constitution need be amended to correct it, the rights of individuals are protected by law from majority actions that would supersede them.
Analogous to this, the powers of small-population areas, like Delaware and Wyoming, are protected from incursion by the Federal government in part by the fact that they are equally represented in the Senate. One need only read any of the gun control threads to pick up on the idea that the majority of citizens, living in urban areas, are largely clueless as to the situation faced by people living 30 miles from the nearest law enforcement agency. Likewise, the majority of people in, say, California, are clueless as to the needs of farmers in the Great Plains, and the latter likewise regarding problems in questions of water rights in the Southwest. The policy of equal representation in the Senate serves to counteract this sort of ignorance.