The most haunting case I read about was the one involving California Highway Patrolman Mark Saylor and his family. He was driving a loaner Lexus while his own car, an earlier model Lexus, was in the shop. Had just picked the car up that morning.
I can’t find the link now, but when it first happened I read a very detailed account. His wife called 911 from within the car trying to get help. Eventually they rear-ended another vehicle while travelling at over 100 mph, left the highway and hit a tree. The car overturned and caught fire, killing all four passengers.
The account I read included a statement from another driver, who said she passed the car while it was moving slowly and “bucking” as if it was stalling. After she passed, she saw it pull to the shoulder as if stopping… then it passed it again at a high rate of speed. Apparently what was happening there was that he was applying the brakes hard as she passed, but they couldn’t hold the car back. Eventually the disks overheated (NHTSB investigation found the rotors heavily damaged from heat) and there was no way to stop it.
The particular car has an oddly-configured shift selection lever, where it’s non-intuitive to find the “neutral” position when you’re used to the normal straight-line layout. And a push-button ignition switch; you have to hold the button in for three seconds to turn the engine off. Those were two factors that the investigation found may have contributed; being unfamiliar with the vehicle as well as trying to keep it on the road at uncontrolled high speeds likely prevented him from taking those obvious actions to stop it.
The final determination was that the car had the wrong floor mat, and that the accelerator had probably been caught on it. That was also Toyota’s determination. Of course, that made it the dealer’s fault; the dealer claimed it was an electrical problem so Toyota’s fault.
Toyota recently made an undisclosed settlement to the family, but as far as I know the case against the dealer hasn’t yet come to a close.