What actors have been in the most non-related films together?

John Turturro, Steve Buscemi and John Polito were all in “Miller’s Crossing” and “Barton Fink”.

Since lots of directors draw on the same ensemble for lots of movies, could all John Ford movies or all John Huston or Orson Welles movies be said to be “related”? I don’t know for a fact that Fellini used the same people over and over again but my impression is that he did. Welles drew heavily from his Mercury Theater clique in his early films.

Jimmy Stewart and June Alyson played husband and wife in 3 films
The Glenn Miller Story
Strategic Air Command
The Stratton Story

Humprey Bogart and Lauren Bacall were in 4 movies together
To Have and Have Not
The Big Sleep
Dark Passage
Key Largo