A post on another topic reminded me that I’ve seen Tom Hanks and Meg Ryan star opposite each other in 3 films: Joe vs. the Volcano, You’ve Got Mail, and Sleepless in Seattle. As far as I know, they don’t have anything to do with each other, unless there was some kind of volcano fetish theme running in the background of all 3 films.
What other famous actors have been cast in movies together where the plot is unrelated? I know Matt Damon and Ben Affleck are friends, so they’ve been in a few movies together. Probably ditto for married couples. Has there been multiple movies where 3 or more of the same famous actors had significant roles?