Given the total dissimilarities between these two societies, I would think that neither had knowledge of the other–and they certainly had no trade.
Their calendars show no similarities. The Maya had a written/carved language that the Aztecs inherited and reshaped while the Inca had nothing similar. (The Inca did have a system of knotting ropes as mnemonic devices for carrying messages, but nothing that would be classified as a written language.) There were no shared food crops. (Some may argue that the distinct climates of the Andes vs Central America prohibited dispersion of food, but the Incas did have a (small) presence in the tropical region of South America contiguous to Central America.) There was no exchange of weapons or domesticated animals that are not nearly as dependent on climate.
On the other hand, several food crops developed in Central America did make the transition to North America, although the fairly large Northern Mexican desert slowed that process considerably. For whatever reason, shipbuilding never caught on as a major effort in the Caribbean Basin, so exchanges between, say the Aztec and the Natchez never blossomed, although we cannot conclusively say that they were unaware of each other.
English settlers landing on the Atlantic coast were told of the Great Lakes by the more southernly Indian nations before the French wandered inland to find them based on the tales of the northen nations.
There was probably some knowledge of places “beyond,” although there may not have been any specific curiosity to explore or identify such places.