That’s how I’d do it, too, growing up with the Legion of Doom, rather than comic books.
Then again, I would defer to comic experts. I would never think Riddler and Solomon Grundy were Batman’s arch-enemy over Joker or Penguin. And I wouldn’t have known from the show that Gorilla Grodd was a Flash enemy.
Pretty sure on Apache Chief vs Giganta, though… except Wiki said she was originally a Wonder Woman foe.
I’d say the same as the OP for the first part. Kingpin would take me to Spiderman because he first appeared there. Deathstroke I barely recall, never much of a DC fan except for Supes and the Bat.
Deathstroke is just a ripoff of Deadpool anyway.
Other way around.
So does Spider-Man: The Sinister Six.
Trancephalic:
Mister Mind might indeed be the greatest villain ever conceived, but the iconic Captain Marvel/Shazam villain is Doctor Sivana.
We’re in agreement that for the Fantastic Four, it’s Dr. Doom over Galactus?
I personally preferred the F4 vs Galactus match-up but that’s not what is being asked.
Oh, yeah, it’s clearly Doom.
Not a bad choice, but the main villain for the Big Red Cheese is Doctor Thaddeus Bodog Sivana.
It has been 20 years since I was into comic books but from what I recall
Silver surfer - Thanos
Professor X - Magneto
Fantastic four - Doctor Doom (Doctor Doom was one of the best characters)
Wolverine - Sabretooth
I’m going to break a bit with convention, here. The Spider-Man villain with which the general public is most acquainted is Whoever he’s currently fighting in the newspaper strip. The number of people who know the character from the newspaper strip (which one can consume for no effort greater than just happening to idly glance at it while reading other funnies) is probably an order of magnitude greater than those who know him from movies, comic books, or TV shows, all of which require at least some active effort to pursue.
In today’s media market? :dubious:
Anyway, I do follow the Spider-Man strip (a bit) and I couldn’t tell you who the villain is in it right now. I know they’ve got Ant-Man (both of them!) guest starring in it right now, but I’m drawing a complete blank on the villain. It’s a bald white guy who’s not the Kingpin, but that’s about it. It’s not a terribly memorable incarnation of the character in general.
Man, I was always jealous of people who got stuff like spiderman and Simpsons in their newspapers. We got stuff like Hi and Louis.
One of those progressive newspapers, huh?
The Legion of Superheroes group has, as I see it, three potentials. The Legion of Super-Villains, natch, the Fatal Five, and the Time Trapper. I’d have to say the Fatal Five, because three legion members have been KIA and the Five were involved with two of them. OK, they didn’t actually kill Ferro Lad themselves, but they were there when it happened.
For me its Spiderman/Green Goblin
but some of the youngins of a certain generation might days might associate Spiderman with Venom.
What about Wonder Woman? She’s got Cheeta, but Cheeta never seemed to quite have the wherewithal to be the arch nemesis for a heroine of Wonder Woman’s stature. Going by the old comics (with which I’m most familiar) I might elect Ares. Most people probably know her best from the TV series but then she had a different villian every episode.
But see, Venom doesn’t really qualify as a villain. He’s (They’re?) only out for Spider-Man’s blood, otherwise he’s(they’re?) superheroing like Spider-Man, just more brutal and sardonic.
On that note: Venom=Carnage.
For Arrow it would be Merlyn. Different backstory than the show but they at least got the name right. 
For Flash I’d think it was Reverse Flash. Although the entire Rogues Gallery is a good match, I don’t think it is in the popular mind the way Reverse Flash is.
Wonder Woman & Aquaman are exactly right, but again, I don’t know how much the world at large knows about the heroes, never mind their foes.
There was some point in time where that was true. The comic strip started after the great popularity of the comic books and far more people followed Spidey that way for a while. Now I think far more people are familiar with the movies than the comic strip which must be declining along with newspapers in general.