what effects how painful an injection (vaccination) is?

Reason I ask is because when I get a flu shot (intramuscular injection into my upper arm) I barely feel the injection and have no residual soreness. On the other hand, the last time I had a Td (or Tdap, don’t remember) booster, it was injected into basically the same muscle and that was significantly more painful with the site being sore for the rest of the day. I didn’t get a look at the syringe to see; is it the size of the needle? or the actual substance being injected?

My WAG is it’s both the substance and the injection site, not the needle size per se.

The skill of the person giving it to you. Same with blood draws. If the phlebotomist is good, you barely feel a thing.

I have had lots of legal injections. And the most painful has always been a tetanus booster.

Most people find the tetanus booster more painful than other shots. This article suggests that it might be related to properties of the bacteria.

Yellow Fever is the worst I’ve ever had.

I’ve also heard that the Gardasil vaccine is often quite painful.

Plus, some vaccines only inject a fraction of a milliliter, whereas the tetanus vaxes, whether alone or in combination, are an ml.

MMR is given sub-q, which is another issue altogether.

I have administered nearly a thousand (estimate) tetanus shots. Usually people are pleasantly surprised when I’m done. They were anticipating much worse.

Needles used in intramuscular (IM) injections have 2 size parameters. Gauge and length.
Gauge is a measure of the outer dimension of the needle, how thick it is. The thicker a needle, the larger the inside diameter. A more viscous medicine, needs a larger diameter inner bore. Length is primarily important for how deep your needle needs to penetrate.

The needles used for tetanus are small. Not the smallest available, but close.

The substance being injected, the size of the needle, the amount being administered, and the speed at which it is injected can all affect the amount of pain. AND every body is different. Tetanus vaccination which is usually administered as a combination vaccine with diphtheria and pertussis (in the US), uses just 0.5 ml of fluid, a small amount.

Now get ready to be scared…Any one who has had a one shot treatment for various bacterial infections (cough syphilis cough) has had the MOST painful IM shot commonly used. Penicillin is very viscous (thick) and needs a large gauge needle. The usual dose is 2ml, 4X the size of the tetanus shot. Additionally it needs to be administered deep in muscular tissue. Usually the butt.

I think there might be an element of dumb luck too. I’m diabetic and inject insulin twice a day. Sometimes I literally don’t feel it at all. Other times it stings a bit. Very rarely it stings quite a bit and I wind up rubbing the spot for a few minutes. I guess it just depends on whether I hit a nerve or not.

In my experience – this. My regular nurse/tech is a wizard and can hit me with any kind of needle anywhere and I never notice. I’ve been to a couple where simplest shot can be a visit to the Pit of Misery. The hands, IMHO, matter more than the substance or placement.

They never bother me. I also gave blood 2 - 3 times a year for over 30 years in a variety of locations, and that never hurt either.

The pneumonia vaccine I just got made my shoulder sore, but only hours after the shot, so that was a side effect, not the injection.

I’ve had the tetanus/etc booster shot five times at ten-year intervals. Four of those times, no appreciable soreness afterward. ONE of those times, my are was so sore that I could barely move it for a whole week!

When I had a tetanus shot a few years ago, I thought the syringe was filled to the 1ml mark; maybe it’s changed in the meantime.

And prior to that, when I was a volunteer at a free clinic, I dispensed a few of those penicillin shots designed for syphilis (can’t recall the brand right now). The hospital where I worked had them too but I don’t remember ever dispensing one. Anyway, it was a huge syringe with a really big needle on it, and required TWO injections because a 4ml IM injection would be painful AND dangerous. That hospital also had some smaller Bicillin syringes for people who came in and either needed a lot of penicillin right now, or (more likely) for whatever reason probably couldn’t be relied upon to take a 10-day course of meds.

Ceftriaxone also produces a very painful IM injection, even when it’s diluted with lidocaine.

p.s. Has anyone had a vaccination that was given with an air gun? Does the military still do that? Anyway, I remember when I was in grade school in the early 1970s and the health department came to the school and gave shots to kids whose parents gave permission, due to some kind of outbreak, most likely measles. I didn’t get the shot, but most of my classmates did, and they did indeed use an air gun which left a lot of them bruised. Anyway, what did that feel like relative to needles?

Me too. I fainted. Only time I ever have, and I’m not at all squeamish about needles. Although that was also the 3rd vaccination I received at the same time.

I have had the penicillin shot twice for syphilis and it is awful. Of course, it’s made even more fun by sitting a bumpy bus on the way home.

I have to inject myself every two weeks (I’m on Humira). If I don’t let the hypo warm up for about 10-15 minutes, the injection process will be unpleasant because what I am injecting is cold.

And every once in a blue moon, I’ll get a dull needle. That is NEVER pleasant!

Yeah, they lined us up in boot camp in the late 60s, air guns on both sides. I didn’t like them, and they left a welt.

The two worst were some sort of booster that left my arm so sore I could barely lift it; and the other was a gamma globulin in the ass just before I left Vietnam, that gave me a hitch in my giddy-up for a day.

1976 swine flu outbreak.

CMC fnord!

Same here, I also do Humira and I agree, I need to let it sit out before doing the injection. I also find if I do it immediately after wiping the area with alcohol it hurts more.

I think this is the case. I have gotten an allergy shot from the same nurse every three weeks for years, and it was every week for a couple years before that. It’s almost always nearly painless, but once in a while she has an off day and it really stings.