After a steroid molecule binds to a receptor and then enters the cell nucleus to instruct the cell to increase protein synthesis, what happens to the steroid molecule? Does it remain in the cell, or can it leave the cell and move on to another cell?
If you don’t get an answer here, you should ask around over at T-Nation.
Usually, metabolism happens. The nucleus contains enzymes which break down steroids:
The whole process is probabilistic though, so it’s likely that some steroid molecules bind to nuclear receptors, fall off, escape the nucleus and the cell, and then enter other cells where they bind in the nucleus…