According to wikipedia the enzymes 11-beta HSD2, 5-alpha reductase and 5-beta reductase all play a role in the metabolism of cortisol.
11-beta HSD2 converts cortisol to cortisone, the other two enzymes convert it into forms of tetrahydrocortisol.
But no mention is made if any is the main pathway, or if all 3 are major pathways. I don’t know if the 11-beta HSD2 converts 90% of cortisol and the other two enzymes only convert 10%, or how much goes in each pathway.
Does anyone know?