I was thinking of posting this myself, but I had reservations. I mean, I work in Downtown, but I don’t live there. I’d never live in Downtown. Too noisy for me, too many homeless, panhandlers, etc. Gangbangers often cause problems at special events. You’d have to live with the sound of sirens on probably a daily basis. Parking a car would be out of the question, unless you’re wealthy. And, while “recreational” shopping is well-provided-for, I don’t know of all that many nearby grocery stores.
Yet, people do live downtown. Also, you have to specify what you mean by “downtown,” at least in the case of Portland. There aren’t that many residents of “Downtown” proper, but there are other “districts” of the city that most anyone would consider to be downtown, but are called by their district name (e.g., The Pearl, Northwest, etc.). These areas tend to have more of the residents.
So, Portland is a YMMV contender.