So far the answer seems to be Goon Show.
Which just goes to show, the answer to everything is always Spike Milligan.
A more recent contender than the Goon Show, although it’s not for comedic effect, but does serve as punctuation of sorts:
In “Dirty Dancing (1987),” Patrick Swayze drags the needle just before Neal (Neil?) tells him that he wants him to do. . . The Pechanga!.
Living Doll with Cliff Richard & The Young Ones (1986) ends with one of these, cutting Rick off before he can utter an expletive.
It was indeed used in “Weird Science,” when Lisa and the boys first walk into the Kandy Bar.