Oh fuck no. Mexico to Canada is 1280 miles, more or less. I actually drove from Seedro Wooley, WA to Redlands, CA. Driveway to driveway it was 1280.3 miles.
As for the latter statement, I refer you to Tim Cahill’s wonderful book Road Fever, which details his record-setting run from Tierra del Fuego to Prudhoe Bay. The only part you can’t drive is the Darien Gap.
I got you all beat 
Cape Kennedy, Florida or do they call it Cape Canaveral now?
to Rota, Spain via FBM submarine two weeks crossing the Atlantic Ocean to patrol area in the Med through the Straits of Gibraltar twice going and coming back underneath a passing cargo ship to hide our sound signature from Russian submarines and on to the submarine tender stationed on the Atlantic side.
All done in 90 days non-stop, but some fast attacks stay out 6 months and longer.
Driving: Miami to Minneapolis. That took 28 hours, but it was during the national 55 mph speed limit days.
Flying: LA to Sydney. Pro tip: Don’t get a window seat on that flight unless you really enjoy looking at either water or a lot of dark.
Some tricks -
Chew ice cubes (truck drivers do this).
Caffeine is good but I avoid coffee because it makes me have to pee. I prefer cold drinks like Pepsi or Mt. Dew.
Dont eat very much and if you do, cut out carbs and starches because those induce melatonin which is a natural sleep hormone. When I do long drives I sip a cold Pepsi and chew on beef jerky.
Know your limits. The second you nod off or start hallucinating, pull over. I dont care what the hurry is its not worth dieing for.
Pearl Harbor, HI, to the North Pole, in the fall of 1983, aboard USS Tautog (SSN 639). I wasn’t timing it, but I think we took 10 - 14 days to get there.
I once drove from central Mexico to Kansas with my wife as a passenger (we did it in three days). We drove the length of the entire state of Tamaulipas without her going to the bathroom, because she was justifiably eeked out by roadside public facilities (gas stations or convenience eating establishments) – she finally relieved her poor bladder in Macallen, Texas, something like nine hours later. I think the entire day’s drive was about twelve hours.
Akron, Ohio to San Francisco.
I once had to drive from Cleveland, Ohio to Fort Myers, Florida for a funeral. Drove and only stopped for fuel and food and potty breaks.
Drove from Phoenix AZ to Tulsa OK a couple years ago.
Also lucky to have survived without crashing.
I used to drive east coast to Kansas a couple of times a year. 24 hours with 2 stops for gas and pee at the same places each time. When the sun came up over the plains around hour 22, the world was a surreal place. Fortunately, those last two hours of the drive were easy.
I’m getting tired just reading about some of these journeys.
Flight: Amsterdam-Johannesburg, approx. 12 hours non-stop. I’ve also done Houston-Abu Dhabi, 20 hours total, but 4 were layover in Frankfurt.
Driving: a couple dozen drives of 12 hours or so each with the only stops made for gas and pee breaks. One of these was over the top of the Andes from Quito, Ecuador to a little flyspeck town in the Amazon basin, dirt road nearly all the way, so that probably gets the highest difficulty index. I never attempt longer trips without an overnight stopover. Longest single non-stop drive probably 300 miles or so (or one tankful).
Train: Chicago-Seattle, about 45 hours.
Walking: about eight miles, from a distant Paris suburb into the city, during a sudden transport strike.
You know they do sell these portable john things.
I knew a guy who would just pee into a jug and dump it out the window.
Between Tokyo and New York City. Airplane.
I’ve done Pittsburgh to Orlando enough to have it down pat at 17&1/2 hours just stopping for gas and maybe twice for food. I’ve also done some iron britches rides on the motorcycle. But my hero is my old boss from Autoworld ---- he actually did the Cannonball Baker Sea-to-Shining-Sea race a couple times. He was the one the van was based on in the movie.
In that case, I personally have orbited the sun non-stop more than 30 times. 
I’ve traveled over 967,745,361,600 kilometers toward The Great Attractor without ever stopping.
Driving myself, from Mobile to Seattle without stopping to sleep, although I’m sure I catnapped for an hour or so once or twice. It took about 80 hours, there were no interstates in those days. I was 23. Much older, with interstates, Cincinnati to Oakland, which I think took about 55 hours. I picked up a hitchhiker, and might have dozed a little while he drove.
A few African trains, 40 hours or so, impossible to sleep, Dakar to Bamako. Third class, hard wooden benches, only wide enough for two people seated, floors way too dirty to lie down on. Egyptian border to Khartoum, just as bad and much more crowded with constant dust blowing through.
Yellowstone to Kansas City, MO by way of Montana and South Dakota. 22 hours, if I recall. I did hand off the driving from about Omaha because I was exhausted, but I still didn’t sleep.