There does seem to be a bit of a weird resistance in large segments of the public health community to e-cigarettes. This is a group that happily endorses nicotine replacement therapy (the patches/gum/etc.), but seem to get their knickers in a twist over something that seems to much like smoking. Doctors are not generally known for suffering non-compliance, or even the appearance of non-compliance, lightly, so I wonder if that has anything to do with it. The FDA doesn’t like them, because they were denied the authority to regulate them; bureaucrats don’t like rivals.
That’s too bad, because it would be nice to know if the scientific findings made with respect to nicotine-only intake are of a magnitude that urges caution. But because there seems to be a bit of a moralistic resistance to harm reduction (for instance, one journal article was “There’s no such thing a free lunch … or puff,” suggesting a rather schoolmarmish tone toward the question), which clouds the issue. Are these significant health downsides, or just DARE-esque scaremongering?
Anyway, the three major adverse health effects associated with cigarette smoking are:
[ol]
[li]Cancer[/li][li]Cardiovascular disease (hypertension and atherosclerosis, leading to coronay disease, peripheral vascular disease, and most significantly, to heart attacks, congestive heart failure, and/or strokes)[/li][li] Chronic obstructive pulmonary disease (COPD)[/li][/ol]
So it would be interesting to evaluate inhaled vaporized nicotine on each of the these fronts.
Someone said above that nicotine is possibly carcinogenic, but the source cited was somewhat more equivocal:
[QUOTE=Nicotine - Wikipedia]
Historically, nicotine has not been regarded as a carcinogen and the IARC has not evaluated nicotine in its standalone form or assigned it to an official carcinogen group. While no epidemiological evidence supports that nicotine alone acts as a carcinogen in the formation of human cancer (on the contrary, a mechanism of urinary excretion of nicotine metabolites was identified as the link between smoking and bladder cancer [72]), research over the last decade has identified nicotine’s carcinogenic potential in animal models and cell culture.[73][74] Nicotine has been noted to directly cause cancer through a number of different mechanisms such as the activation of MAP Kinases.[75] Indirectly, nicotine increases cholinergic signalling (and adrenergic signalling in the case of colon cancer[76]), thereby impeding apoptosis (programmed cell death), promoting tumor growth, and activating growth factors and cellular mitogenic factors such as 5-LOX, and EGF. Nicotine also promotes cancer growth by stimulating angiogenesis and neovascularization.[77][78] In one study, nicotine administered to mice with tumors caused increases in tumor size (twofold increase), metastasis (nine-fold increase), and tumor recurrence (threefold increase).[79]
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As to CV function, nicotine alone increases blood pressure. Some recent research suggests that nicotine alone may also accelerate atherosclerosis (hardening of the arteries). (Cite.) It is not clear to me what the size of this effect is, while the articles says “as effective as cigarette smoking,” it doesn’t appear that they have the longitudinal data (tobacco smoking vs. nicotine-only intake) to say that yet.
Finally, as to pulmonary function, I am aware of no pulmonary or respiratory concerns regarding transdermal nicotine, so if there are any health downsides to inhaling nicotine vapor, it is because of that mode of intake. Again, some evidence suggests significant short-term effects (Cite), but it is not clear whether these are particularly severe effects (I’m not a pulmonologist) or persistent in nature.
So there are some health effects, but it is unclear whether they represent the looming perils of a smoking habit (serious enough the one should devote significant time, money, and effort to quit) or something rather less sinister (say like a daily, solitary soda with lunch — nobody’s idea of a healthful habit, to be sure, but by and large fairly benign).