OK - we have these cats that never liked her, it sounds like. Past cats that have.
Get another hospital table and try the bribe route first. You can prep it, roll it up covered, and she can dole the treats out.
Try also different coverings for her lap, if there’s room for a cat to sit there. Some cats are very picky about where and what they sit on. Mine don’t like sitting on my jeans, but will gladly curl up on an inexpensive towel or cheap knit blanket that I got at CostCo (but Target or almost anywhere will carry them). A heating pad under the blanket (at a temp that is comfortable for your wife) might help up the allure.
Basically, your first course of action is to make her and her surroundings more attractive to cats who are not used to considering her an option for treats, attention, warmth, etc. You’re looking for ways to help with that. Even something like a flat cat shelf over the monitor stand that they can lie on and be all superior about might help. Move their cat tree next to her work area, things like that. Increase their opportunities for interactions.
My read is that you have become the primary source for all positive things for most of the cats, and so they don’t even consider her.
Second, if these cats have generally always behaved this way, I don’t think you need to look at her medications or other sources for the behavior. Look at the environment and seek remedies there.
Third, if you spend a period of a few weeks gradually increasing interactions, melding environments, bribing, etc, and nothing is working, you might want to consider, well, a kitten or a small dog. A kitten that she carries around with her and that you enable her as much as possible to be the primary caregiver. It will obviously need to get down and play and do its business, but you’ll need to bring her a food and water station. The kitten should sleep in a pocket or blanket on or near her, etc.
Small dog might be last resort. If she’s really missing a companion animal and the cats just won’t cooperate, there are some really loving little guys out there that love wheelchairs and just chilling.